Results 221 to 230 of about 47,987 (262)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

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Agent‐based models in sociology

WIREs Computational Statistics, 2015
This article looks at 20 years of applications of agent‐based models (ABMs) in sociology and, in particular, their explanatory achievements and methodological insights. These applications have helped sociologists to examine agent interaction in social outcomes and have helped shift analyses away from structural and aggregate factors, to the role of ...
BIANCHI, Federico, SQUAZZONI, Flaminio
openaire   +3 more sources

Agent based modeling of malaria

2014 IEEE Canada International Humanitarian Technology Conference - (IHTC), 2014
This work explores the utility of an agent based model (ABM) for studying malaria prevalence and transmission. Malaria is a life-threatening disease caused by Plasmodium parasites that are transmitted to humans through the bites of infected female mosquitoes of the genus Anopheles.
Chathura Illangakoon, Robert D. McLeod, Marcia R. Friesen   +2 more
openaire   +1 more source

Spatial agent‐based modelling

International Journal of Geographical Information Science, 2006
The convergence of object‐oriented approaches to data modelling within geographic information science together with increasingly fine‐scale data collection approaches and discrete‐event simulations...
Daniel G. Brown 0002, Yichun Xie
openaire   +1 more source

A framework for the comparison of agent-based models

Autonomous Agents and Multi-Agent Systems, 2022
We develop a methodology for comparing agent-based models that are developed for the same domain, but may differ in the data sets (e.g., geographical regions) to which they are applied, and in the structure of the model. Our approach is to learn a response surface in the common parameter space of the models and compare the regions corresponding to ...
Swapna Thorve, Zhihao Hu, Kiran Lakkaraju, Joshua Letchford, Anil Vullikanti, Achla Marathe, Samarth Swarup   +6 more
openaire   +2 more sources

An agent-based model for financial vulnerability [PDF]

Journal of Economic Interaction and Coordination, 2014
This study addresses a critical regulatory shortfall by developing a platform to extend stress testing from a microprudential approach to a dynamic, macroprudential approach. This paper describes the ensuing agent-based model for analyzing the vulnerability of the financial system to asset- and funding-based fire sales.
Rick Bookstaber, Mark Paddrik, Brian Tivnan   +2 more
openaire   +1 more source

Tutorial on agent-based modeling and simulation

Journal of Simulation, 2006
Agent-based modelling and simulation (ABMS) is a relatively new approach to modelling systems composed of autonomous, interacting agents. Agent-based modelling is a way to model the dynamics of complex systems and complex adaptive systems. Such systems often self-organize themselves and create emergent order.
Charles M. Macal, Michael J. North
openaire   +1 more source