Results 171 to 180 of about 11,094,605 (304)

Capturing Argument in Agent-Based Models. [PDF]

Topoi (Dordr)
Assaad L, Fuchs R, Phillips K, Schöppl K, Hahn U.   +4 more
europepmc   +1 more source

Institutional modelling: Adding social backbone to agent-based models. [PDF]

MethodsX, 2022
Ghorbani A.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

BIWT: a bioinformatics walkthrough for embedding spatial multiomics in agent-based models for virtual cells. [PDF]

Bioinformatics
Bergman DR, Johnson JAI, Naji M, Booth M, Lima da Rocha H, Deshpande A, Sidiropoulos DN, Lopez-Vidal T, Heiland R, Kagohara LT, Anders RA, Zheng L, Jaffee EM, Stein-O'Brien G, Macklin P, Fertig EJ.   +15 more
europepmc   +1 more source

Feedback Loops in Opinion Dynamics of Agent-Based Models with Multiplicative Noise. [PDF]

Entropy (Basel), 2022
Djurdjevac Conrad N, Köppl J, Djurdjevac A.   +2 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Generalized Stable Population and Agent-Based Models of Phenotypic Transmission in Human Populations, with an Application to Body Size. [PDF]

Hum Hered
Aldea N, García-Aguirre A, Beltrán-Sánchez H, Daza S, Palloni A.   +4 more
europepmc   +1 more source

Delayed skeletal muscle repair following inflammatory damage in simulated agent-based models of muscle regeneration. [PDF]

PLoS Comput Biol, 2023
Khuu S, Fernandez JW, Handsfield GG.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Astrocyte Reprogramming Drives Tumor Progression and Chemotherapy Resistance in Agent-Based Models of Breast Cancer Brain Metastases. [PDF]

Bull Math Biol
Kaur R, Barker-Clarke R, Dhawan A.
europepmc   +1 more source