Results 141 to 150 of about 2,565,092 (318)
Agent-based coordination for the sensor web
, 2010 Presented at the 25th annual ACM Symposium on Applied Computing (SAC'10), Sierre, Switzerland, March 22-26 2010The approach described advocates the use of a multi-agent system, and specifically the use of multi-agent distributed constraint optimisation ...
Gregory M. P. O. Hare +8 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Safety and Security Issues Related with the Transportation, Storage and Disposal of Pesticides
EDIS, 2018 This article covers the imporatant steps in assuring that the transporting pesticides that are deemed hazardous by the Secretary of Transportation, Secure Pesticide Storage and Proper Disposal of Pesticide Waste.
Laurie Ann Hurner
doaj
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
EDIS, 2017 The article describes the sections of the Pesticide label and discusses the importance of each.
Laurie Ann Hurner
doaj
Verifiable Semantics for Agent-to-Agent Communication
CoRRMultiagent AI systems require consistent communication, but we lack methods to verify that agents share the same understanding of the terms used. Natural language is interpretable but vulnerable to semantic drift, while learned protocols are efficient but opaque.
Philipp Schoenegger +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Obligation Norm Identification in Agent Societies [PDF]
Most works on norms have investigated how norms are regulated using institutional mechanisms. Very few works have focused on how an agent may infer the norms of a society without the norm being explicitly given to the agent.
Martin K. Purvis +3 more
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