Results 11 to 20 of about 1,765,270 (268)

Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition

open access: yesExperimental and Molecular Medicine, 2019
Cancer: How a plant metabolite analog suppresses tumor growth A synthetic analog of a chemical found in fruit suppresses tumor growth by targeting an RNA-binding protein (hnRNPA2B1) and preventing the production of a pro-cancer regulatory factor.
Nak-Kyun Soung   +21 more
doaj   +1 more source

Simulating Immune Interference on the Effect of a Bivalent Glycoconjugate Vaccine against Haemophilus influenzae Serotypes “a” and “b”

open access: yesCanadian Journal of Infectious Diseases and Medical Microbiology, 2016
Objective. We sought to evaluate the immune responses to a bivalent Haemophilus influenzae glycoconjugate vaccine against serotypes “a” (Hia) and “b” (Hib) in the presence of the preexisting immunity to Hib. Methods.
Angjelina Konini   +2 more
doaj   +1 more source

New Cyclic Lipopeptides of the Iturin Class Produced by Saltern-Derived Bacillus sp. KCB14S006

open access: yesMarine Drugs, 2016
Salterns, one of the most extreme natural hypersaline environments, are a rich source of halophilic and halotolerant microorganisms, but they remain largely underexplored ecological niches in the discovery of bioactive secondary metabolites. In continued
Sangkeun Son   +16 more
doaj   +1 more source

Remote Debugging Mechanism Based on MILS Multi-level Security Architecture [PDF]

open access: yesJisuanji gongcheng, 2016
Aiming at the features of multi-level security architecture,and the remote debugging technology based on the Multiple Independent Levels of Security(MILS) multilevel security architecture,this paper proposes a unified management and synergic debugging ...
LI Jian,CHEN Ge,YE Xiaoyun,FU Kai,HE Wei
doaj   +1 more source

Research Supervision Management Via A Multi-Agent Framework

open access: yesAdvances in Distributed Computing and Artificial Intelligence Journal, 2014
In this paper, we propose an agent-based framework to enhance, control and manage the research supervision process. The proposed framework consists of three phases which are Research Development Activities, Performance and Completion Measurement, and ...
Omar JASSIM   +2 more
doaj   +1 more source

The Application of Artificial Intelligence Models for Food Security: A Review

open access: yesAgriculture, 2023
Emerging technologies associated with Artificial Intelligence (AI) have enabled improvements in global food security situations. However, there is a limited understanding regarding the extent to which stakeholders are involved in AI modelling research ...
Rebecca Sarku   +2 more
doaj   +1 more source

Oral Metronomic Topotecan Sensitizes Crizotinib Antitumor Activity in ALKF1174L Drug-Resistant Neuroblastoma Preclinical Models

open access: yesTranslational Oncology, 2017
BACKGROUND: Anaplastic lymphoma kinase (ALK) inhibitor crizotinib has proven to be effective in the treatment of ALK-mutated neuroblastoma, but crizotinib resistance was commonly observed in patients.
Libo Zhang, Bing Wu, Sylvain Baruchel
doaj   +1 more source

Cost-effectiveness of a potential Zika vaccine candidate: a case study for Colombia

open access: yesBMC Medicine, 2018
Background A number of Zika vaccine platforms are currently being investigated, some of which have entered clinical trials. We sought to evaluate the cost-effectiveness of a potential Zika vaccine candidate under the WHO Vaccine Target Product Profile ...
Affan Shoukat   +2 more
doaj   +1 more source

Pharmacology of Sedation Agents and Reversal Agents [PDF]

open access: yesDigestion, 2010
Sedation for gastrointestinal endoscopies is obtained by opioids, benzodiazepines, propofol, ketamine and/or droperidol. The pharmacokinetic profile of some sedatives/anesthetics renders them advantageous over others. Opioids, mainly pethidine and fentanyl, are the most popular.
Fassoulaki, A.   +2 more
openaire   +3 more sources

Agent-as-a-Judge: Evaluate Agents with Agents

open access: yesCoRR
Contemporary evaluation techniques are inadequate for agentic systems. These approaches either focus exclusively on final outcomes -- ignoring the step-by-step nature of agentic systems, or require excessive manual labour. To address this, we introduce the Agent-as-a-Judge framework, wherein agentic systems are used to evaluate agentic systems. This is
Mingchen Zhuge   +12 more
openaire   +3 more sources

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