Results 21 to 30 of about 102,215 (303)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Entendimiento agente y razón práctica

Tópicos, 2013
This work shows the central role of the agent intellect, not only in speculative knowledge (as amply described by the Scholastics) but also in practical knowledge.
José Angel García Cuadrado
doaj   +1 more source

Philosophy of Intellect in the Long Commentary on the De anima of Averroes [PDF]

, 2012
In the Long Commentary on the De anima, Averroes posits three separate intelligences in the anima rationalis or the rational soul: agent intellect or intellectus agens, material or passible intellect, intellectus possibilis or intellectus passibilis, and
Hendrix, John S
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Agent Intellect and Black Zones [PDF]

, 2018
This essay addresses arguments regarding the “place” or “non-place” in which ideas originate and whether they are wholly transcendental, wholly contingent, or a combination of transcendental and contingent.
Keeney, Gavin
core  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

La voluntad como primer motor creado en Francisco Suárez

Scientia et Fides, 2017
The will as first mover created in Francisco SuárezThe aim of this paper is to show that Francisco Suarez’s claim that the will is the prime mover of the human actions is grounded in his own metaphysical system. For that purpose, I argue that the will is
Mauricio Lecón Rosales
doaj   +1 more source

Unconscious Thought in Peripatetic Philosophy [PDF]

, 2014
In Aristotle’s De anima 3.5, the relation between intellect and thought, and between thought and object, is not accessible to discursive or conscious thought; an understanding of the relation requires nous, intuitive or “unconscious” thought. The “active”
Hendrix, John S
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Agent Intellect and Divine Illumination in Thomas Aquinas’ Summa Theologiae

Cauriensia
The theory of knowledge of Thomas Aquinas is strongly influenced by the Aristotelian theory of abstraction and the agent intellect. Along with this theory, Thomas Aquinas also assimilates the Augustinian doctrine of divine illumination. In our paper, we
Martín F. Echavarría Anavitarte
doaj   +1 more source