Results 41 to 50 of about 102,215 (303)

The agent intellect according to Capreolus and Cajetan [PDF]

open access: yes, 2014
En este trabajo se estudia la versión del intelecto agente según dos grandes comentadores tomistas del s. XV: Capreolo y Cayetano. El primero sostuvo que el intelecto agente es la misma alma; el segundo, que su realidad es una actividad, que es acto ...
Sellés, Juan Fernando
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Averroes and the Philosophical Account of Prophecy [PDF]

open access: yes, 2018
Prophecy is conspicuous by its complete absence from all three of the commentaries on De Anima by Averroes. However, prophecy and philosophical metaphysics are discussed by him in his Commentary on the Parva Naturalia, a work written before his ...
Taylor, Richard C.
core   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

La Imaginación en Avempace

open access: yesTópicos, 2013
Aristotle's first commenter, followed by Averroes, Avempace with the Arab Muslim tradition, performs an important role in the issue of human imagination, distinguishing three levels, which are: 1) Epistemological: imagination as a mediative role between ...
Joaquín Lomba
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

El intelecto agente en algunos maestros franciscanos del s. XVII: Rafael Aversa, Juan Lalemandet, Guillermo van Sichen, Buenaventura Columbo, Bartolomé de Barberis y Wolter Schopen / The active intellect in several Franciscan’s masters on XVIIth century..

open access: yesCauriensia, 2017
Resumen En este trabajo se estudia el parecer de seis maestros franciscanos del s. XVII sobre el intelecto agente: Rafael Aversa, Juan Lalemandet, Guillermo van Sichen, Buenaventura Columbo, Bartolomé de Barberis y Wolter Schopen Palabras clave ...
Juan Fernando Sellés Dauder
doaj   +2 more sources

Multi-Agent Deep Reinforcement Learning with Human Strategies

open access: yes, 2019
Deep learning has enabled traditional reinforcement learning methods to deal with high-dimensional problems. However, one of the disadvantages of deep reinforcement learning methods is the limited exploration capacity of learning agents.
Nahavandi, Saeid   +2 more
core   +1 more source

A Comprehensive Overview of the Clinical, Electrophysiological, and Neuroimaging Features of BPAN: Insights From a New Case Series

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Neurodegeneration with brain iron accumulation (NBIA) comprises a genetically and clinically heterogeneous group of rare neurological disorders characterized particularly by iron accumulation in the basal ganglia. To date, 15 genes have been associated with NBIA.
Seda Susgun   +95 more
wiley   +1 more source

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