Results 61 to 70 of about 2,482,632 (267)
SciPost PhysicsThe substantial data volumes encountered in modern particle physics and other domains of fundamental physics research allow (and require) the use of increasingly complex data analysis tools and workflows. While the use of machine learning (ML) tools for data analysis has recently proliferated, these tools are typically special-purpose algorithms that ...
Sascha Diefenbacher +5 more
openaire +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
工程科学学报, 2016 Pumping agents can improve the fluidity of paste slurries. However,the effecting mechanism of pumping agents on the coagulability of paste slurries is not made clear.
LI Gong-cheng +3 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
ACTIVE DATABASES, BUSINESS RULES AND REACTIVE AGENTS – WHAT IS THE CONNECTION?
Journal of Information and Organizational Sciences, 2012 These three technologies were and still are mainly treated separately. Since notmuch work has been carried out in defining and combining them together, we are going topresent what has been done and put accent on what could be done.
Kornelije Rabuzin +2 more
doaj
ROLE OF BACTERIA AND MICROSCOPIC FUNGI IN AETIOLOGY OF CHRONIC SUPPURATIVE OTITIS MEDIA
Медицинский вестник Юга России, 2014 Purpose: To research of spectrum of agents and their biological characteristics in chronic suppurative otitis media (CSOM).Materials and Methods: Вacterial and fungous flora in the middle ear of 102 patients aged from 20 to 70 years with CSOM were ...
L. I. Vasilieva +4 more
doaj +1 more source
, 2016 This paper contributes to the formal research on legal interpretation by presenting a structure of normative agents. Each normative agent consists of a knowledge base, a set of preferences, and certain procedures related to the interpretation conducted by this agent. A part of typology of normative agents is presented.
Michal Araszkiewicz, Tomasz Zurek
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source