Results 211 to 220 of about 467,070 (267)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Daily-level associations between sleep hygiene, cannabis use, and sleep health outcomes. [PDF]

Health Psychol
Livingston NR, Looby A.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Effects of Particle Size and Replacement Ratio of Ceramsite on Permeability Characteristics of Lightweight Concrete via Pore Structure and Fractal Approach. [PDF]

Materials (Basel)
Liu Z, Xu Y, Zhuang S, Ren J.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Vegetation-Mediated Soil Organic Carbon Differentiation and Carbon Sequestration Strategies in a Typical Wetland of the North China Plain. [PDF]

Plants (Basel)
Shi Z, Wang Y, Li X, Zhang N, Li S, Wang Y, Lin H, Dong Y, Zhou H, Wu D, Cheng M.   +10 more
europepmc   +1 more source

Dispersion Mechanism of Conductive Phase Materials and Micro-Mechanical Properties of ERCC. [PDF]

Materials (Basel)
Min Q, Zhang M, Feng D, He Y, Li H, Wang Y.   +5 more
europepmc   +1 more source

Gradation Design of Epoxy-Asphalt Mixtures for Steel Bridge Deck Pavements Optimized for Skid Resistance in Hot and Humid Climates. [PDF]

Polymers (Basel)
Du P, He Q, Han Z, Zhang Q, Xiong C, Zhang Y.   +5 more
europepmc   +1 more source

Research on the creep behavior of tunnel lining concrete based on a multi-scale approach. [PDF]

Sci Rep
Lan L, Mu J, Liu Y, Li Y, Liu J.
europepmc   +1 more source

Study on mechanical properties and microstructure of soil-cement solidified recycled aggregate concrete using bridge demolition waste. [PDF]

PLoS One
Du Y, Cheng Z, Cai P, Lou K, Wei S, Wang X, Wang S, Mao X, Huang F, Wu Q.   +9 more
europepmc   +1 more source