Results 191 to 200 of about 2,715,691 (402)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

ALKALI-SILICA REACTIVITY OF PORTLAND-COMPOSITE CEMENTS AND GRAVEL AGGREGATES [PDF]

, 2018
Jadvyga Žvironaitė
openalex   +1 more source

WHAT DOES A DRY SEASON MEAN TO THE WESTERN AUSTRALIAN ECONOMY? A CGE INVESTIGATION [PDF]

In this paper, by applying a Computable General Equilibrium model for Western Australia (called WAG), the impact of the 2002 dry season on the State’s wider economy is quantitatively analysed.
Islam, Nazrul
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Microshear Bond Strength of Composite Resin to Mineral Trioxide Aggregate and Potassium Nitrate-Modified Polycarboxylate Cement at Two Time Points Using Different Adhesive Approaches: An In Vitro Study. [PDF]

Clin Exp Dent Res
Adl A, Jowkar Z, Zerafat M, Sobhnamayan F.   +3 more
europepmc   +1 more source

PUMICE STONE ENGINEERING AND RICE HUSK ASH LIGHT AGGREGATE MATERIAL TO INCREASE THE COMPRESSIVE STRENGTH OF COMPOSITE LIGHTWEIGHT CONCRETE

, 2020
Moh Azhar, Atjep Soedarjanto, Anugraha Syah   +2 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Strength and Ductility Enhancement in Coarse-Aggregate UHPC via Fiber Hybridization: Micro-Mechanistic Insights and Artificial Neural Network Prediction. [PDF]

Materials (Basel)
Wang J, Wang Y, Wang S, Zhan Y, Peng Y, Hu Z, Zhang B.   +6 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Research Progress on Asphalt-Aggregate Adhesion Suffered from a Salt-Enriched Environment. [PDF]

Materials (Basel)
Liu Y, Deng W, Peng L, Lai H, Zong Y, Chang M, Xiong R.   +6 more
europepmc   +1 more source