Results 201 to 210 of about 2,715,691 (402)
Amino Acid Composition drives Peptide Aggregation: Predicting Aggregation for Improved Synthesis
Peptide aggregation is a long-standing challenge in chemical peptide synthesis, limiting its efficiency and reliability. Although data-driven methods have enhanced our understanding of many sequence-based phenomena, no comprehensive approach addresses so-called “non-random difficult couplings” (generally linked to aggregation) during solid-phase ...
Bálint Tamás +3 more
openaire +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Study on Enhanced Oil Recovery of Nanofluid-Polymer Binary Flooding Technology in Medium-High Permeability Reservoirs. [PDF]
Polymers (Basel)Yang L +7 more
europepmc +1 more source
On the European readiness for flexicurity: Empirical evidence with OECD/HBS methodologies and reform proposals [PDF]
The Fourth European Working Conditions Survey (European Foundation 2007) is used to investigate the readiness of Europe to flexicurity labour market reforms proposed by the European Commission (= flexibilization of employment relations compensated by ...
Tangian, Andranik
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Comprehensive evaluation of sound absorption performance in porous concrete pavement with crushed stone base course. [PDF]
Sci RepZhang Y, Wang H, Khair A, Yang J, Han Y.
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Properties of Eco-Friendly Cement Composites Made with Recycled Cement Mortar-Based Artificial Aggregates. [PDF]
Materials (Basel)Kalinowska-Wichrowska K +6 more
europepmc +1 more source