Results 81 to 90 of about 295,094 (360)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Automated Verification of Design Patterns with LePUS3 [PDF]

, 2009
Specification and [visual] modelling languages are expected to combine strong abstraction mechanisms with rigour, scalability, and parsimony. LePUS3 is a visual, object-oriented design description language axiomatized in a decidable subset of the first ...
Eden, Amnon H, Gasparis, Epameinondas, Kazman, Rick, Nicholson, Jonathan   +3 more
core   +3 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Experimental assessment on mechanical performance of precast concrete sandwich panels manufactured with mixed recycled aggregate

Case Studies in Construction Materials
Mixed recycled coarse aggregate (MRA), derived from construction and demolition waste of masonry-concrete composite frame structures, primarily consists of recycled concrete aggregate (RCA) and recycled brick aggregate (RBA).
Jian Ma, Pengpeng Yan, Xu Liu
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Indonesian Stock Market Crisis Observation with Spectral and Composite Index [PDF]

The paper discusses the employment of the index composed from the dynamical tree of correlations among stock prices both with the popularly used standard (conventional) composite one.
Situngkir, Hokky
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Alternative Estimation of Effective Young’s Modulus for Lightweight Aggregate Concrete LWAC

Fracture and Structural Integrity, 2020
The prediction of effective mechanical properties of composite materials using analytical models is of significant practical interest in situations in which tests are impossible, difficult, or costly.
Meriem Fakhreddine Bouali, Hima Abdelkader   +1 more
doaj  

Performance Evaluation of Open Graded Base Course with Doweled and Non-Doweled Transverse Joints [PDF]

, 2010
The objectives of this study were to investigate the performance of 20-year old doweled/non-doweled and dense-graded/permeable base test sections on three concrete pavement segments in Wisconsin: USH 18/151 in Iowa and Dane counties, STH 29 in Brown ...
Crovetti, James, Owusu-Ababio, Samuel, Schmitt, Robert   +2 more
core   +1 more source