Results 51 to 60 of about 11,642 (310)

Material Issues in Layered Forming [PDF]

open access: yes, 1993
A brief overview of key issues in layered thermal processing is given. Incremental sintering and layered fusion ofpowder and molten droplets are discussed.
Amon, Christina   +6 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Bond behavior of self consolidating concrete [PDF]

open access: yes, 2016
The new generation of innovative projects has led to the use of greater amounts of reinforcement and the development of concrete with specific characteristics. It is necessary to use a material that ensures the uniformity of the cross section, as well as
Aguado de Cea, Antonio   +2 more
core   +3 more sources

Aggregate interlocking of open-graded friction courses with compaction effort

open access: yesJournal of the National Science Foundation of Sri Lanka, 2019
Densification of open-graded friction course (OGFC) makes it inefficient, with the reduction of air void content due to aggregate breakage by over compaction efforts. Therefore, it is important to identify the optimum compaction effort to accomplish the most stable aggregate on aggregate contact of internal aggregate structure with increasing ...
WK Mampearachchi   +2 more
openaire   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Tunable Digital Material Properties of 3D Voxel Printers [PDF]

open access: yes, 2008
Digital materials are composed of many discrete voxels placed in a massively parallel layer deposition process, as opposed to continuous (analog) deposition techniques.
Hiller, Jonathan, Lipson, Hod
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Significance of Fines in Hot Mix Asphalt Synthesis

open access: yesRomanian Journal of Transport Infrastructure, 2017
According to their size, aggregates are classified in coarse grained, fine grained, and fines. The determination of fines content in aggregate materials is very simple and is performed through the aggregate washing during the sieving procedure to define ...
Kalaitzaki Elvira   +2 more
doaj   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick   +19 more
wiley   +1 more source

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