Results 71 to 80 of about 51,164 (264)

Extension of multi-commodity closed-loop supply chain network design by aggregate production planning

Logistics Research, 2016
In this work the influence of production and capacity planning on decisions regarding facility location, distribution quantities and component remanufacturing (and vice versa) in a closed-loop supply chain network (CLSCN) with multiple make-to-order ...
Leena Steinke, Kathrin Fischer
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Production Planning and Aggregate Production Planning

, 2017
Competition has a direct impact on the growth of the economy. Manufacturing systems can be improved by a well-thought-out production strategy. Problems with aggregate production planning and sales forecasting are leading an Installation Elevator Company to be unable to deliver items on time and have an impact on customer satisfaction.
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Aggregate Planning of Human Resource

Iraqi Administrative Sciences Journal, 2018
The research is beginning due to the importance or necessity to find Solution about the Variable demand for medical services preparation& diagnosed the suitable strategies for human Resource Aggregate planning in teaching Al-kadhimyiah hospital as a result of spreading specialist doctors.
Ghassan Qasim Dawood Al – Lami, Anwar Mazhar Suhail   +1 more
openaire   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Research on the Operation Optimization of Aggregate Resources under the Dual Factors of Power Grid and Economy [PDF]

E3S Web of Conferences
Under the influence of power grid and economy, the operation optimization of aggregate resources has high practical value and significance. For the problems of the existing aggregate resource operation optimization methods, this paper presents a ...
Feng Hua, Zhang Chengxiang, Zhang Hanbing, Ye Jichao, Ding Ning, Xu Yonghai   +5 more
doaj   +1 more source

On aggregation in production planning [PDF]

Engineering Costs and Production Economics, 1982
Abstract There is a renewed interest in aggregate planning and hierarchical production planning, see for instance Axsater [1] and Hax and Meal [4]. But there are not yet many results on the relationship between the characteristics of the production system and the right stratification of the production planning process.
openaire   +2 more sources