Results 101 to 110 of about 1,091,962 (285)

Formation of Cosmic Dust Bunnies

, 2007
Planetary formation is an efficient process now thought to take place on a relatively short astronomical time scale. Recent observations have shown that the dust surrounding a protostar emits more efficiently at longer wavelengths as the protoplanetary ...
Freed, Michael S., Hayes, Ryan L., Hyde, Truell W., Matthews, Lorin S.   +3 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Single‐Molecule Multi‐Channel Conductance Assisted by Through‐Space Conjugation

SmartMat
Molecular electronics has emerged and evolved within the context of the miniaturization of silicon‐based microchips, with the purpose to achieve conducting functions by integrating individual molecules into circuits through a “bottom‐up” approach, but ...
Shaoxin Song, Jinshi Li, Yi Xiong, Ben Zhong Tang, Zujin Zhao   +4 more
doaj   +1 more source

What drives the dust activity of comet 67P/Churyumov-Gerasimenko?

, 2015
We use the gravitational instability formation scenario of cometesimals to derive the aggregate size that can be released by the gas pressure from the nucleus of comet 67P/Churyumov-Gerasimenko for different heliocentric distances and different volatile ...
Blum, J., Gundlach, B., Keller, H. U., Skorov, Y. V.   +3 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Aggregation Operators

, 2013
It was in 1990, when I was still studying my degree in Computer Science, when I met Prof. Lotfi Zadeh for the first time, if I do not remember wrongly. It was in a conference I was participating in Barcelona where he gave one of the plenary talks. I remember clearly that he mentioned fuzzy systems and the successful Japanese applications of the late ...
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Exploring and leveraging aggregation effects on reactive oxygen species generation in photodynamic therapy

Aggregate
Aggregate‐level photodynamic therapy (PDT) has attracted significant interest and driven substantial advances in multifunction phototheranostic platforms. As exemplified by two typical instances of aggregation‐caused quenching of reactive oxygen species (
Zeyan Zhuang, Jianqing Li, Pingchuan Shen, Zujin Zhao, Ben Zhong Tang   +4 more
doaj   +1 more source

Templating aggregation

Physical Review E
We introduce an aggregation process based on \emph{templating}, where a specified number of constituent clusters must assemble on a larger aggregate, which serves as a scaffold, for a reaction to occur. A simple example is a dimer scaffold, upon which two monomers meet and create another dimer, while dimers and larger aggregates undergo in irreversible
P. L. Krapivsky, S. Redner
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source