Results 51 to 60 of about 203,000 (258)

Structural Plasticity and Noncovalent Substrate Binding in the GroEL Apical Domain. A study using electrospray ionization mass spectrometry and fluorescence binding studies [PDF]

, 2002
Advances in understanding how GroEL binds to non-native proteins are reported. Conformational flexibility in the GroEL apical domain, which could account for the variety of substrates that GroEL binds, is illustrated by comparison of several independent ...
Adams, Boisvert, Braig, Braig, Brinker, Brocchierei, Brunger, Brunger, Buckle, Bukau, Chatellier, Chatellier, Chatellier, Chen, Collaborative Computational Project, N., Coyle, Dessauer, Ewalt, Feltham, Fenton, Ferrige, Grallert, Hartl, Hartl, HayerHartl, Hemmingsen, Hlodan, Houry, Hunt, Hutchinson, Jancarik, Jones, Jones, Kobayashi, Konermann, Kraunsoe, Kusmierczyk, Landry, Landry, Leslie, Loo, Ma, Murshudov, Navaza, Pace, Pflugrath, Ploegman, Raftery, Ranson, Robinson, Romano, Roseman, Rye, Sigler, Smith, Smote, Tanaka, Wang, Weber, Weber, Weissman, Xu, Zahn   +62 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Molecular Engineering‐Boosted High‐Performance AIE Sonosensitizer for Cancer Sonodynamic‐Augmented Immunotherapy

Aggregate
Immunogenic cell death (ICD) has been demonstrated as a reliable approach to improve therapeutic effect in cancer treatment by triggering antitumor immunity. However, the trigger of ICD on the basis of chemotherapy and phototherapy meets the obstacles of
Chao Fu, Wei Zhao, Xionglei Wang, Xia He, Yuting Yin, Jiayi Li, Qiyun Deng, Caihong Yan, Yuli Yin, Zhiming Wang, Rong Hu   +10 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Room Temperature Phosphorescent Nanofiber Membranes by Bio‐Fermentation

Advanced Science
Stimuli‐responsive materials exhibiting exceptional room temperature phosphorescence (RTP) hold promise for emerging technologies. However, constructing such systems in a sustainable, scalable, and processable manner remains challenging.
Xiaolin Nie, Junyi Gong, Zeyang Ding, Bo Wu, Wen‐Jin Wang, Feng Gao, Guoqing Zhang, Parvej Alam, Yu Xiong, Zheng Zhao, Zijie Qiu, Ben Zhong Tang   +11 more
doaj   +1 more source

Dust Emissivity Variations In the Milky Way [PDF]

, 2009
Dust properties appear to vary according to the environment in which the dust evolves. Previous observational indications of these variations in the FIR and submm spectral range are scarce and limited to specific regions of the sky.
Abergel, Abergel, Allamandola, Bacmann, Bazell, Bennett, Bernard, Boulanger, Boulanger, C. Mény, Cambrésy, Cambrésy, Cambrésy, Caselli, D. Paradis, Dale, Dame, Delabrouille, Dickey, Draine, Draine, Dupac, Désert, Finkbeiner, Fixsen, Fixsen, J.-Ph. Bernard, Kemper, Lagache, Laureijs, Laureijs, Laureijs, Macias-Perez, Magnani, Mathis, Mény, Puget, Stepnik, Stepnik, Strong, Tielens, Tielens, Tristram, Van de Bult   +43 more
core   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Aggregation‐induced emission systems involving supramolecular assembly

Aggregate, 2020
Aggregation‐induced emission (AIE), as an exciting photophysical phenomenon, has been regarded as one frontier research topic within both ranges of molecular luminescence and materials science over the last two decades.
Xin‐Yue Lou, Ying‐Wei Yang
doaj   +1 more source

Cost-benefit analysis of climate change – A methodological overview of recent studies [PDF]

, 2012
Global warming16 has already begun. Climate change has become a self-propelling and self-reinforcing process as a result of the externality associated with greenhouse- gas (GHG) emissions.
Szijártó, Norbert
core  

Ultrasound-induced transformation of fluorescent organic nanoparticles from a molecular rotor into rhomboidal nanocrystals with enhanced emission [PDF]

, 2014
Fluorescent organic nanoparticles (FONs) based on aggregation-induced emission (AIE) are receiving increasing attention owing to their simple preparation, enhancedoptical properties, and a wide range of applications.
Barone, Vincenzo, Bottari, Giovanni, Brancato, Giuseppe, Guldi, Dirk M., Koenig, Matthias, Torres, Tomás   +5 more
core   +2 more sources