Results 41 to 50 of about 799,944 (293)

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

FLavourite: Horizontal and Vertical Federated Learning Setting Comparison

IEEE Access
Federated learning (FL) enables multiple organizations to collaboratively train AI models while keeping data separate. Depending on data distribution, FL can be set up horizontally (HFL) or vertically (VFL). When multi-modal data are already available in
Walter Riviera, Ilaria Boscolo Galazzo, Gloria Menegaz   +2 more
doaj   +1 more source

Paraspeckles: Paragons of functional aggregation [PDF]

Journal of Cell Biology, 2015
Low-complexity proteins undergo phase separation in vitro, forming hydrogels or liquid droplets. Whether these form in vivo, and under what conditions, is still unclear. In this issue, Hennig et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201504117) show that formation of the paraspeckle, a nuclear body that regulates gene expression ...
Courchaine, Edward, Neugebauer, Karla M.
openaire   +2 more sources

Potential Early Risk Biomarkers for Reduced Forced Expiratory Volume in Children Post‐Hematopoietic Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We sought to identify potential early risk biomarkers for lung disease in children post‐allogeneic HCT. Patients with pulmonary function tests 3 months post‐transplant and plasma samples between days 7 and 14 post‐HCT were included. Six of 27 subjects enrolled had reduced forced expiratory volume 1 (FEV1) z scores.
Isabella S. Small, Pi Chun Cheng, April L. Rahrig, Courtney M. Rowan   +3 more
wiley   +1 more source

Ensemble Classifier Based on Interval Modeling for Microarray Datasets

Entropy
The purpose of the study is to propose a multi-class ensemble classifier using interval modeling dedicated to microarray datasets. An approach of creating the uncertainty intervals for the single prediction values of constituent classifiers and then ...
Urszula Bentkowska, Wojciech Gałka, Marcin Mrukowicz, Aleksander Wojtowicz   +3 more
doaj   +1 more source

Lipid oxidation in foods and its implications on proteins

Frontiers in Nutrition, 2023
Lipids in foods are sensitive to various environmental conditions. Under light or high temperatures, free radicals could be formed due to lipid oxidation, leading to the formation of unstable food system.
Lianxin Geng, Kunlun Liu, Kunlun Liu, Huiyan Zhang   +3 more
doaj   +1 more source

Personalizing the Pediatric Hematology/Oncology Fellowship: Adapting Training for the Next Generation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The pediatric hematology‐oncology fellowship training curriculum has not substantially changed since its inception. The first year of training is clinically focused, and the second and third years are devoted to scholarship. However, this current structure leaves many fellows less competitive in the current job market, resulting in ...
Scott C. Borinstein, Melissa J. Rose, Scott Moerdler, Richard Ho   +3 more
wiley   +1 more source

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

The Chaperonin GroESL Facilitates Caulobacter crescentus Cell Division by Supporting the Functions of the Z-Ring Regulators FtsA and FzlA

mBio, 2021
All organisms depend on mechanisms that protect proteins from misfolding and aggregation. GroESL is a highly conserved molecular chaperone that functions to prevent protein aggregation in organisms ranging from bacteria to humans.
Kristen Schroeder, Kristina Heinrich, Ines Neuwirth, Kristina Jonas   +3 more
doaj   +1 more source

Choquet-Inspired Aggregation Functions

Information Fusion
In this work, we propose a new family of aggregation functions inspired by the well-known Choquet integral. To build these functions, we replace the measure in the definition of the Choquet integral by an appropriate function. We study the properties of these aggregation functions and explore the relations with some other common aggregation functions ...
H. Bustince, R. Mesiar, G.P. Dimuro, J. Fernandez, J. Lafuente, B. De Baets   +5 more
openaire   +2 more sources