Results 141 to 150 of about 1,608,848 (335)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

On the Equivalence between Welfarism and Equality of Opportunity [PDF]

A welfarist way of allocating resources consists in 1) equipping individuals with comparable indices of their well-being and 2) applying a unique aggregation rule to individual well-being levels.
Francois Maniquet
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Measurement and Analysis of Child Well-Being in Middle and High Income Countries [PDF]

The European Journal of Comparative Economics, 2008
Starting from the recent UNICEF publications on child poverty in the developed countries, which received a wide audience in the political and scientific world, in this paper we further analyze the UNICEF study data base and present three composite ...
Almas Heshmati, Arno Tausch, Chemen S. J. Bajalan   +2 more
doaj  

Anomaly Detection Based on Aggregation of Indicators

, 2014
Automatic anomaly detection is a major issue in various areas. Beyond mere detection, the identification of the origin of the problem that produced the anomaly is also essential. This paper introduces a general methodology that can assist human operators who aim at classifying monitoring signals.
Rabenoro, Tsirizo, Lacaille, Jérôme, Cottrell, Marie, Rossi, Fabrice   +3 more
openaire   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Study on the aggregation patterns of fleas parasitizing the great gerbil (Rhombomys opimus) in the Junggar Basin plague natural focus

Parasites & Vectors
Background The great gerbil (Rhombomys opimus), whose ectoparasitic fleas significantly influence the transmission and prevalence of plague, was the dominant rodent species in the Junggar Basin in Northwestern China.
Fang Li, Guoyu Zhao, Yu Wang, Shang Zhan, Xine Tang, Tao Luo, Abulimiti Moming, Huiqian Wang, Jianhui Chen, Qiguo Wang, Haiyan Wu, Yujiang Zhang   +11 more
doaj   +1 more source

Multidimensional poverty and material deprivation [PDF]

We examine the measurement of multidimensional poverty and material deprivation following the counting approach. In contrast to earlier contributions, dimensions of well-being are not forced to be equally important but different weights can be assigned ...
Conchita D'Ambrosio, Satya R. Chakravarty, Walter Bossert   +2 more
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source