Results 251 to 260 of about 752,343 (341)

Precise Control of Drug Release in Machine Learning‐Designed Antibody‐Eluting Implants for Postoperative Scarring Inhibition in Glaucoma

open access: yesAdvanced Healthcare Materials, EarlyView.
We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin   +5 more
wiley   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

open access: yesAdvanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro   +4 more
wiley   +1 more source

Understanding and Addressing Bullying in Children and Adolescents. [PDF]

open access: yesJ Korean Acad Child Adolesc Psychiatry
Harsono CS, Febriyana N.
europepmc   +1 more source

Enhancing Magnetic Hyperthermia at the Cell Membrane by Anchoring 92R‐Functionalized Magnetic Nanoparticles to Low‐Endocytic CCR9 Surface Receptors

open access: yesAdvanced Healthcare Materials, EarlyView.
We present a strategy to enhance magnetic hyperthermia therapy by modulating nanoparticle–cell interactions. Antibody‐functionalized magnetic nanoparticles targeting the low‐internalizing CCR9 receptor enable spatially controlled membrane anchoring, reducing aggregation and maximizing heat generation under alternating magnetic fields.
David Egea‐Benavente   +5 more
wiley   +1 more source

Geometrical Designs in Volumetric Bioprinting to Study Cellular Behaviors in Engineered Constructs

open access: yesAdvanced Healthcare Materials, EarlyView.
Curvature and spatial confinement guide cell behavior in volumetrically printed 3D constructs. Endothelial cells align and spread along specific geometries, while metastatic osteosarcoma cells proliferate independently of structural cues. Label‐free holographic microscopy captures real‐time, long‐term cell–material interactions, highlighting Gel‐PEG's ...
Julia Simińska‐Stanny   +3 more
wiley   +1 more source

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