Effect of topical application of melatonin on serum levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in patients with type 1 or type 2 diabetes and periodontal disease [PDF]
Background: The present clinical trial study was designed to assess the effect of topical application of melatonin on serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) in patients with diabetes and ...
Cutando Soriano, Antonio +4 more
core +1 more source
Role of Interleukin-17 in immunopathology of chronic and aggressive periodontitis
Interleukin-17 (IL-17) is a pro-inflammatory cytokine which is derived from T-cells. It is a strong agent of inflammation in inflammatory condition including the periodontitis.
A. Wankhede, P. Dhadse
semanticscholar +1 more source
From Disease to Illness: Reframing Periodontitis Through an Anthropological Lens
Periodontitis is at once a disease, an illness, and a sickness—where biological pathology, lived experience, and social meaning intersect. The proposed integrated model links upstream structural actions with downstream clinical and educational practices through feedback loops that promote equitable and effective prevention and care.
Carlo Galli +3 more
wiley +1 more source
Autoimmunity and Periodontitis
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga +2 more
wiley +1 more source
Correlation of periodontal pathogens in concurrent endodontic-periodontal diseases [PDF]
Objectives: This study investigated the correlation between Tannerella forsythia, Porphyromonas gingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans at dual sites in concurrent endodonticperiodontal diseases.
Bajrović, Kasim +5 more
core +1 more source
Hand to Mouth: A Systematic Review and Meta-Analysis of the Association between Rheumatoid Arthritis and Periodontitis [PDF]
Background: Rheumatoid arthritis (RA) and periodontitis are both chronic inflammatory diseases, which demonstrate similarities in terms of mechanism, histopathology, and demography. An association between these conditions has been demonstrated previously
Abou-Raya +57 more
core +2 more sources
Epigenetic regulation of inflammation in localized aggressive periodontitis
We have previously demonstrated a Toll-like receptor (TLR)-mediated hyper-responsive phenotype in our cohort of localized aggressive periodontitis (LAP) individuals. However, mechanisms related to this phenotype are still not clear in the literature. The
L. Shaddox +5 more
semanticscholar +1 more source
Disease Staging Index for Aggressive Periodontitis.
Major advances in the knowledge about the aetiopathogenesis of aggressive periodontitis (AgP) have been achieved. An ever increasing number of scientific articles related to AgP are published every year contributing significantly to the knowledge of this unique and complex disease.
Ramachandra, Srinivas Sulugodu +3 more
openaire +3 more sources
This graphical abstract illustrates the role of matrix metalloproteinases (MMPs) across the pathogenesis, diagnosis, and therapeutics of periodontal and peri‐implant diseases. Microbial and host stimuli trigger MMP activation leading to extracellular matrix breakdown, point‐of‐care aMMP‐8 detection aids diagnosis, and adjunctive or AI‐assisted ...
Timo Sorsa +5 more
wiley +1 more source

