Results 161 to 170 of about 131,390 (268)

Systemic redox imbalance correlates with clinical aggressiveness and poor prognosis in canine inflammatory mammary carcinoma. [PDF]

Front Vet Sci
Fontes TN, Hielm-Björkman A, Vieira-Filho CHDC, de Carvalho VMP, Silva LP, de Oliveira VAP, Canuto GAB, de Sá HC, de Moura FBC, Barrouin-Melo SM, Fonseca-Alves CE, Estrela-Lima A.   +11 more
europepmc   +1 more source

Matrix Stiffness Directs Stemness Signatures in Breast Cancer

Advanced Healthcare Materials, EarlyView.
We built lab‐grown breast cancer models to study how the stiffness of the tumor's surroundings influences cancer behavior. Softer environments encouraged more stem‐like, drug‐resistant cells, while stiffer ones kept cells more differentiated. These findings show that tissue mechanics drive cancer diversity and drug resistance, offering new insights for
Chantal Kopecky, Elvis Pandzic, Sean Porazinski, J Justin Gooding, Kristopher A Kilian   +4 more
wiley   +1 more source

A Machine Learning Framework Integrating DeepLabCut and SimBA for Quantifying Aggressive Behavior in Swimming Crab <i>Portunus trituberculatus</i>. [PDF]

Animals (Basel)
Ding C, Fu Y, Zhou Z, Chen T, Xia W, Huang W, Zhou B, Chen J, Zheng C, Wang C, Mu C, Liu C, Liu L.   +12 more
europepmc   +1 more source

Gellan Gum Fluid Gel System for Controlled‐Delivery of Cytokine‐Licensed MSC‐EVs to Enhance Corneal Repair in Limbal Stem Cell Deficiency

Advanced Healthcare Materials, EarlyView.
Gellan gum fluid gel (FG) enables controlled ocular delivery of mesenchymal stromal cell (MSC)‐derived extracellular vesicles (EV). Its shear‐thinning, solid‐liquid‐solid rheology ensures prolonged ocular retention. Sustained MSC‐EV release (∼18% in 6 hrs) supports effective EV ocular delivery.
Seyedmohammad Moosavizadeh, Ava Dashti, Thomas E. Robinson, Robyn Gaffey, Richard Moakes, Neil Lagali, Liam Grover, Thomas Ritter   +7 more
wiley   +1 more source

Glutamine metabolism in ovarian carcinoma: disentangling tumor aggressiveness from chemoresistance. [PDF]

Transl Cancer Res
Hélage S.
europepmc   +1 more source

Mixed‐Metal Promotion in a Manganese‐Molybdenum Oxynitride as Catalyst to Integrate C─C and C─N Coupling Reactions for the Direct Synthesis of Acetonitrile from Syngas and Ammonia

Advanced Materials, EarlyView.
Transition metal oxy/carbo‐nitrides show great promise as catalysts for sustainable processes. A Mn‐Mo mixed‐metal oxynitride attains remarkable performance for the direct synthesis of acetonitrile, an important commodity chemical, via sequential C─N and C─C coupling from syngas (C1) and ammonia (N1) feedstocks.
M. Elena Martínez‐Monje, Wilson Henao, Tania Rodenas, Patricia Concepción, Virginia Pérez Dieste, Alexander Missyul, Giovanni Agostini, Gonzalo Prieto   +7 more
wiley   +1 more source

High mannose content of mesenchymal glioblastoma correlates with hydroxyl proton transfer-weighted (HPTw) MRI as noninvasive biomarker of tumor aggressiveness. [PDF]

Sci Adv
Ghaemi B, Lopez-Bertoni H, Kuddannaya S, Sall S, Laterra J, Liu G, Bulte JWM.   +6 more
europepmc   +1 more source

Bioorthogonal Photoactivation of 2‐Nitrobenzyl Caged Doxorubicin Anticancer Prodrugs on Gold Nanostars

Advanced Materials, EarlyView.
Bioorthogonal chemistry was applied to intracellularly photoactivate Doxorubicin (Dox) using gold nanostars (AuNSt) and near‐infrared (NIR) light. Two prodrugs were used: one photoactivatable, masked with 2‐nitrobenzyl carbamate (proDox1) and another photolabile, masked with 2‐nitrobenzyl diol (proDox2), which was attached to the AuNSt surface.
Juan José Esteve‐Moreno, Andrea Escudero, Oscar Ferreira Silvestre, José Manuel Terrés, Mónica Gorbe, Eva Garrido, Carlos Renero‐Lecuna, Judith Langer, María Alfonso, Javier Ibañez, Félix Sancenón, Roberto Cao‐Milán, Luis M. Liz‐Marzán, Alba García‐Fernández, Andy Hernández‐Montoto, Ramón Martínez‐Máñez   +15 more
wiley   +1 more source

Weight trajectories throughout adulthood and prostate cancer incidence, aggressiveness, and death in 258 494 men. [PDF]

J Natl Cancer Inst
da Silva M, Fritz J, Elhakeem A, Jochems SHJ, Sun M, Mboya IB, Häggström C, Wahlström J, Michaëlsson K, Magnusson PKE, Lagerros YT, Lönnberg L, Chabok A, Elmståhl S, Nwaru BI, Kankaanranta H, Hedman L, Backman H, Hägg S, Stattin P, Tilling K, Stocks T.   +21 more
europepmc   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source