Results 31 to 40 of about 18,276 (179)

Quantifying single nucleotide variant detection sensitivity in exome sequencing [PDF]

, 2013
BACKGROUND: The targeted capture and sequencing of genomic regions has rapidly demonstrated its utility in genetic studies. Inherent in this technology is considerable heterogeneity of target coverage and this is expected to systematically impact our ...
A McKenna, AJ Coffey, Alison M Meynert, AM Sulonen, Andrew P Jackson, B Lehne, B Timmermann, DN Cooper, E Kalay, H Li, H Li, J Parla, JF Degner, JK Teer, K Fransen, KK Mantripragada, Louise S Bicknell, M Choi, MA Depristo, Martin S Taylor, Matthew E Hurles, MD Mailman, MJ Clark, MN Bainbridge, MW Hahn, R Leinonen, RA Harte, RE Thurman, SB Ng, SB Ng, SB Ng, SS Ajay, The International HapMap 3 Consortium, Y Li, Y Xu   +34 more
core   +2 more sources

Sexual Safety Signals of Common Antidiabetic Drugs: Insights From FAERS Disproportionality Analysis

Andrology, EarlyView.
ABSTRACT Background Erectile dysfunction is a prevalent and distressing complication of diabetes mellitus that markedly affects quality of life in male patients. Although the role of diabetes in erectile dysfunction is well‐established, potential drug‐induced sexual dysfunction associated with commonly prescribed antidiabetic medications remains ...
Shan Lin, Xuefeng Ding, Xin Dang, Qingyuan Zhan   +3 more
wiley   +1 more source

Self-Modification of Policy and Utility Function in Rational Agents

, 2016
Any agent that is part of the environment it interacts with and has versatile actuators (such as arms and fingers), will in principle have the ability to self-modify -- for example by changing its own source code.
B Hibbard, D Dewey, D Silver, J Schmidhuber, L Orseau, L Orseau, L Orseau, LP Kaelbling, M Hutter, M Hutter, M Ring, N Bostrom, R Sutton, RV Yampolskiy, S Legg, V Mnih   +15 more
core   +1 more source

Enhancing generalizability theory with mixed‐effects models for heteroscedasticity in psychological measurement: A theoretical introduction with an application from EEG data

British Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Generalizability theory (G‐theory) defines a statistical framework for assessing measurement reliability by decomposing observed variance into meaningful components attributable to persons, facets, and error. Classic G‐theory assumes homoscedastic residual variances across measurement conditions, an assumption that is often violated in ...
Philippe Rast, Peter E. Clayson
wiley   +1 more source

A Case for Machine Ethics in Modeling Human-Level Intelligent Agents [PDF]

, 2018
This paper focuses on the research field of machine ethics and how it relates to a technological singularity—a hypothesized, futuristic event where artificial machines will have greater-than-human-level intelligence.
Boyles, Robert James M.
core  

Coincident onset of multiple sclerosis and herpes simplex virus 1 encephalitis. a case report [PDF]

, 2017
Background: Along with vitamin D, smoking, body mass index and others, Epstein Barr virus, other herpesviruses and human endogenous retroviruses represent plausible environmental risk factors for multiple sclerosis.
Buscarinu, M. C., Ferraldeschi, Michela, Fornasiero, Arianna, Renie', Roberta, Ristori, Giovanni, Romano, Silvia, Salvetti, Marco, Trasimeni, Guido   +7 more
core   +2 more sources

Dementia Risk in Type 1 and 2 Diabetes: A Nationwide Population‐Based Comparison

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Diabetes is increasingly recognised as a major contributor to cognitive decline and dementia, but the risk varies by diabetes type and treatment intensity. We compared the risk of all‐cause dementia, Alzheimer's disease (AD) and vascular dementia (VaD) among individuals with and without diabetes.
Ji Eun Jun, Seohyun Kim, In‐Kyung Jeong, Jae Hyeon Kim   +3 more
wiley   +1 more source

From Disciplinary Silos to Cyber-Transdisciplinary Networks: A Plural Epistemic Model for AGI-Era Knowledge Production [PDF]

Journal of Systemics, Cybernetics and Informatics
This article extends a keynote from the 16th IMCIC 2025, offering a framework for academic institutions navigating the epistemic shifts prompted by artificial general intelligence (AGI). It argues that traditional disciplinary (Mode 1), interdisciplinary
Cristo Leon, James Lipuma
doaj  

Impact of Simulated Risk Factor Management on Cardiovascular Disease and Costs in Type 2 Diabetes Using the ABC Model

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims We evaluated the impact of scenario‐based multifactorial control on the 3‐year incidence of fatal/non‐fatal cardiovascular disease (CVD) and associated healthcare costs in Asian patients with type 2 diabetes (T2D). Materials and Methods We applied the validated ‘ABC’ model to simulate the 3‐year impact of attaining multiple treatment ...
Lee‐Ling Lim, Eric S. H. Lau, Juliana N. M. Lui, Linong Ji, A. G. Unnikrishnan, Sirinart Sirinvaravong, Siew‐Pheng Chan, Soo Lim, Andrea O. Y. Luk, Juliana C. N. Chan   +9 more
wiley   +1 more source

Artificial Intelligence and Public Trust [PDF]

, 2017
The future is here. With the exploding commercial market for high-powered, cloud-computing AI services provided by the likes of Amazon, Microsoft, and Google, the reach of artificial intelligence technologies is virtually unlimited.
Vallor, Shannon
core   +1 more source