Results 271 to 280 of about 12,311,713 (381)

DNA methylation and prediction of biological age. [PDF]

Front Mol Biosci
Chen Y, Cheng X, Ji S.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Aging, natural death, and the compression of morbidity.

New England Journal of Medicine, 1980
J. Fries
semanticscholar   +1 more source

Integrative epigenetics and transcriptomics identify aging genes in human blood. [PDF]

Nat Commun
Moqri M, Ying K, Poganik JR, Herzog C, Chen Q, Emamifar M, Tyshkovskiy A, Eames A, Mur J, Glubokov D, Matei-Dediu B, Goeminne L, Mitchell W, McCartney DL, Salas LA, Marioni RE, Lasky-Su JA, Snyder MP, Gladyshev VN.   +18 more
europepmc   +1 more source

Premarin has opposing effects on spatial learning, neural activation, and serum cytokine levels in middle-aged female rats depending on reproductive history

, 2018
Liisa A.M. Galea, Meighen Roes, Christina Dimech, Carmen Chow, Rand Mahmoud, Stephanie E. Lieblich, Paula Duarte‐Guterman   +6 more
openalex   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Selection for Postponed Senescence in Drosophila melanogaster Reveals Distinct Metabolic Aging Trajectories Modifiable by the Angiotensin-Converting Enzyme Inhibitor Lisinopril. [PDF]

Aging Cell
Vecchié D, Anholt RRH, Mackay TFC, De Luca M.   +3 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Biological Age Should Anchor Age-Related Disease Research. [PDF]

Aging Dis
Shakeel H, Jin D, Jin K.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source