Results 31 to 40 of about 2,655 (260)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Adat Law as a Foundation for Advancing Indonesian Agrarian Law to Maximise Societal Welfare

Sriwijaya Law Review
The evolution of agrarian law in Indonesia, particularly land law, must adhere to the constitutional mandate of promoting the welfare of the populace. This subject is compelling because existing studies predominantly address the legal-formal dimensions ...
Firman Muntaqo, Febrian Febrian, Alip Dian Pratama   +2 more
doaj   +1 more source

Agrarian diet and diseases of affluence – Do evolutionary novel dietary lectins cause leptin resistance?

BMC Endocrine Disorders, 2005
Background The global pattern of varying prevalence of diseases of affluence, such as obesity, cardiovascular disease and diabetes, suggests that some environmental factor specific to agrarian societies could initiate these diseases.
Jönsson Tommy, Olsson Stefan, Ahrén Bo, Bøg-Hansen Thorkild C, Dole Anita, Lindeberg Staffan   +5 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Fake spawns and floating particles: a rebuttal of Karkarey et al. “Alternative reproductive tactics and inverse size-assortment in a high-density fish spawning aggregation”

BMC Ecology, 2018
Courtship and spawning behaviors of coral reef fishes are very complex, and sufficient sampling effort and proper methods are required to draw informed conclusions on their mating systems that are grounded in contemporary theories of mate choice and ...
Brad E. Erisman, João P. Barreiros, Kevin L. Rhodes, Robert R. Warner   +3 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

“Agrarian Unrest” in Central Black Earth Region in Autumn 1905

Научный диалог
The study draws on documents from the first department of the Ministry of Justice regarding "agrarian unrest" in the Central Black Earth region in autumn 1905, housed in the Russian State Historical Archive.
V. A. Ippolitov
doaj   +1 more source

THEORETICAL ASPECTS OF THE DIGITAL ERA: STAGES OF DEVELOPMENT, MAJOR TRENDS, THE NEED TO CREATE A DIGITAL PLATFORM FOR AGRARIAN AND INDUSTRIAL COMPLEX

Известия высших учебных заведений. Поволжский регион: Общественные науки, 2020
Background. Digitalization processes that transform into an unparalleled economic system require the digital transformation of agrarian and industrial enter-prises based on the consistent development of a digital platform and state support for this ...
V. M. Volodin, N. A. Nad'kina
doaj   +1 more source