Results 221 to 230 of about 7,983,895 (297)

Influence of Ecological Zones and Honey Bee Morphometric Traits on the Physicochemical Properties of Honey in Kazakhstan. [PDF]

Foods
Toishimanov M, Nuraliyeva U, Moldakhmetova G, Torekhanov M, Sheralieva Z, Khalykova G, Spatay N, Skryl A, Krupskiy T, Mustafin K.   +9 more
europepmc   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Vaccination coverage and inequalities in childhood immunisation in Ethiopia: a secondary analysis of the PMA national longitudinal survey. [PDF]

BMJ Open
Hagos A, Tariku MK, Mekuriya GE, Abuhay HW, Demoze L, Masresha GA, Aweke MN, Getahun HA, Chanie ST, Yitageasu G, Alemu GG.   +10 more
europepmc   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Modeling the rise and demise of Classic Maya cities: Climate, conflict, and economies of scale. [PDF]

Proc Natl Acad Sci U S A
McCool WC, Codding BF, Degnan B, Ebert CE, Johnson ES, Vernon KB, Wilson KM, Beach T, Prufer KM, Kennett DJ.   +9 more
europepmc   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

In This Issue. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

HIV Seroprevalence, Incidence, and Viral Suppression Among Ugandan Female Bar Workers: A Population-Based Study. [PDF]

J Acquir Immune Defic Syndr
Feng X, Nakigozi G, Patel EU, Kennedy CE, Shrestha S, Nalugoda F, Kigozi G, Ssekubugu R, Chang LW, Wirtz AL, Fitzmaurice AG, Nakawooya H, Kigozi G, Galiwango RM, Reynolds SJ, Kagaayi J, Tobian AAR, Grabowski MK.   +17 more
europepmc   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Mechanistic Insights into Wildlife Cancer and Conservation Strategies Under the One Health Framework. [PDF]

Vet Sci
Wang Q, Feng X, Su Y, Zhang N, Dudnyk Y, He H.   +5 more
europepmc   +1 more source