Results 51 to 60 of about 377,767 (232)

Guidelines' recommendations for the treatment-resistant depression: A systematic review of their quality.

PLoS ONE, 2023
IntroductionDepression is a serious and widespread mental health disorder. A significant proportion of patients with depression fail to remit after two antidepressant treatment trials, a condition named treatment-resistant depression (TRD).
Franciele Cordeiro Gabriel, Airton Tetelbom Stein, Daniela de Oliveira Melo, Gessica Caroline Henrique Fontes-Mota, Itamires Benício Dos Santos, Camila da Silva Rodrigues, Andrea Dourado, Mônica Cristiane Rodrigues, Renério Fráguas, Ivan D Florez, Diogo Telles Correia, Eliane Ribeiro   +11 more
doaj   +1 more source

Additional file 1 of Assessment of the quality of recommendations from 161 clinical practice guidelines using the Appraisal of Guidelines for Research and Evaluation–Recommendations Excellence (AGREE-REX) instrument shows there is room for improvement

, 2020
Additional file 1. List of development organizations of clinical practice guidelines assessed.
Florez, Ivan D., Brouwers, Melissa C., Kerkvliet, Kate, Spithoff, Karen, Alonso-Coello, Pablo, Burgers, Jako, Cluzeau, Francoise, Férvers, Beatrice, Graham, Ian, Grimshaw, Jeremy, Hanna, Steven, Kastner, Monika, Kho, Michelle, Qaseem, Amir, Straus, Sharon   +14 more
openaire   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Strongly sheared stratocumulus convection: an observationally based large-eddy simulation study [PDF]

Atmospheric Chemistry and Physics, 2012
Unusually large wind shears across the inversion in the stratocumulus-topped marine boundary layer (MBL) were frequently observed during VOCALS-REx. To investigate the impact of wind shear on the MBL turbulence structure, a large-eddy simulation (LES ...
S. Wang, X. Zheng, Q. Jiang
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

On the Status of Rights

Voices in Bioethics, 2021
Photo by Patrick Tomasso on Unsplash ABSTRACT In cases where the law conflicts with bioethics, the status of rights must be determined to resolve some of the tensions.
Liam Butchart
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Appraising the quality standard of clinical practice guidelines related to central venous catheter-related thrombosis prevention: a systematic review of clinical practice guidelines

BMJ Open
Objective To evaluate the quality and analyse the content of clinical practice guidelines regarding central venous catheter-related thrombosis (CRT) to provide evidence for formulating an evidence-based practice protocol and a risk assessment scale to ...
Guan Wang, Shuai Zhang, Jing Zhang, Xiuying Hu, Yongya Wu, Wenmo Yao, Faqian Bu, Aoxue Wang   +7 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source