Results 51 to 60 of about 263,905 (237)

A protocol for a systematic review of clinical practice guidelines for the antenatal management of dichorionic diamniotic twin pregnancy [version 1; peer review: 2 approved]

HRB Open Research, 2021
Overview: The protocol outlines the process designed to systematically review clinical practice guidelines (CPGs), addressing the antenatal management of dichorionic diamniotic (DCDA) twin pregnancies.
Caroline O'Connor, Keelin O'Donoghue, Sara Leitao   +2 more
doaj   +1 more source

A Systematic Review of Clinical Practice Guidelines for Managing Pulmonary Toxicities Caused by Immune Checkpoint Inhibitors: Quality of Treatment Recommendations and Differences in Management Strategies Between Guidelines

Clinical Medicine Insights: Oncology, 2023
Background: Pulmonary toxicities caused by immune checkpoint inhibitors are a prominent concern for clinicians. Clinical Practice Guidelines (CPGs) are critical for managing these toxicities.
Kofi N Donkor, Hyeree Jang, Reena Sail
doaj   +1 more source

Systematic Review, Quality Assessment, and Synthesis of Guidelines for Emergency Department Care of Transgender and Gender-diverse People: Recommendations for Immediate Action to Improve Care

Western Journal of Emergency Medicine, 2023
Introduction: We conducted this systematic review to identify emergency department (ED) relevant recommendations in current guidelines for care of transgender and gender-diverse (TGD) people internationally.
Michael I. Kruse, Alexandra Clarizio, Sawyer Karabelas-Pittman, Blair L. Bigham, Suneel Upadhye   +4 more
doaj   +1 more source

Recommendations for the pharmacological treatment of treatment-resistant depression: A systematic review protocol.

PLoS ONE, 2022
IntroductionDepression is a serious and widespread mental health disorder. Although effective treatment does exist, a significant proportion of patients with depression fail to respond to antidepressant treatment trials, a condition named treatment ...
Franciele Cordeiro Gabriel, Airton Tetelbom Stein, Daniela Oliveira de Melo, Géssica Caroline Henrique Fontes-Mota, Itamires Benício Dos Santos, Camila da Silva Rodrigues, Mônica Cristiane Rodrigues, Renério Fráguas, Ivan D Florez, Diogo Telles Correia, Eliane Ribeiro   +10 more
doaj   +1 more source

A systematic review of clinical practice guidelines and recommendations for the management of pain, sedation, delirium and iatrogenic withdrawal syndrome in pediatric intensive care

Frontiers in Pediatrics, 2023
IntroductionThis systematic review aimed to evaluate the quality of clinical practice guidelines (CPGs) and recommendations for managing pain, sedation, delirium, and iatrogenic withdrawal syndrome in pediatric intensive care (PICU).
Ibo MacDonald, Silvia Alvarado, Silvia Alvarado, Mark T. Marston, Mark T. Marston, Luz Gomez Tovar, Luz Gomez Tovar, Vivianne Chanez, Eva Favre, Eva Favre, Ying Gu, Alexia Trombert, Maria-Helena Perez, Anne-Sylvie Ramelet, Anne-Sylvie Ramelet   +14 more
doaj   +1 more source

Clinical practice guidelines for the antenatal management of dichorionic diamniotic twin pregnancies: a systematic review

BMC Pregnancy and Childbirth, 2023
Objective This review aimed to identify guidelines with recommendations applicable to the antenatal management of dichorionic diamniotic twin pregnancies within high-income countries, appraise their methodological quality, and discuss the similarities ...
Caroline O’Connor, Emily O’Connor, Sara Leitao, Shauna Barrett, Keelin O’Donoghue   +4 more
doaj   +1 more source

A critical appraisal of delirium clinical practice guidelines relevant to the care of older adults in the emergency department with a synthesis of recommendations: an umbrella review protocol

Systematic Reviews, 2022
Background Up to 35% of older adults present to the emergency department (ED) with delirium or develop the condition during their ED stay. Delirium associated with an ED visit is independently linked to poorer outcomes such as loss of independence ...
Sarah Filiatreault, Jeremy M. Grimshaw, Sara A. Kreindler, Alecs Chochinov, Janice Linton, Malcolm B. Doupe   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source