Results 81 to 90 of about 315,422 (280)

AGREE II appraisals of pediatric clinical practice guidelines: a systematic review

, 2022
The purpose of the study, in general, is to explore the findings of studies published in the scientific or professional literature that have used the Appraisal of Guidelines for Research and Evaluation II (AGREE II) Instrument (https://www.agreetrust.org/
Ivan D. Florez, Yasser S. Amer
core   +2 more sources

AGREE II scores.

(A)AGREE II domain and overall rating in each CPGs. (B)Average score of each AGREE II domain and overall rating for all CPGs. (C) Average score of each AGREE II item for all CPGs.
Xiaohong Su (451978), Huafeng Pan (5735240), Xiaojun Zheng (7247783), Jiayu Li (720299), Yang Liu (4829), Lang Zhang (37998), Wanchun Li (577714), Jiayin Ou (12132915), Jing Chen (4762)   +8 more
core   +1 more source

Guideline Assessment Project II: statistical calibration informed the development of an AGREE II extension for surgical guidelines

, 2021
Objective: To inform the development of an AGREE II extension specifically tailored for surgical guidelines. Summary background data: AGREE II was designed to inform the development, reporting, and appraisal of clinical practice guidelines.
Mavridis, Dimitrios, Tsokani, Sofia, Francis, Nader K., Bonjer, Hendrik Jaap, Brouwers, Melissa C., Zanninotto, Giovanni, Antoniou, Stavros A., Stefanidis, Dimitrios, Silecchia, Gianfranco, Markar, Sheraz, Morales-Conde, Salvador, López-Cano, Manuel, Moustaki, Irini, Flórez, Ivan D., Antoniou, George A., Hanna, George H.   +15 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Correlations among the AGREE II, AGREE-REX and RIGHT domains.

(A) Heat map of Pearson correlation coefficient between AGREE II, AGREE-Rex, and RIGHT domains. (B) Heat map of P value for correlation between AGREE II, AGREE-Rex, and RIGHT domains, *: p < 0.05, **: p < 0.01, ***: p < 0.001.
Xiaohong Su (451978), Huafeng Pan (5735240), Xiaojun Zheng (7247783), Jiayu Li (720299), Yang Liu (4829), Lang Zhang (37998), Wanchun Li (577714), Jiayin Ou (12132915), Jing Chen (4762)   +8 more
core   +1 more source

Erectile dysfunction management: a critical appraisal of clinical practice guidelines with the AGREE II instrument

, 2022
Our study aimed to assess the methodological strengths and weaknesses of erectile dysfunction clinical practice guidelines (CPGs) for individuals using the AGREE II tool.
GÜDELOĞLU, AHMET, AŞCI, AHMET, HABERAL, HAKAN BAHADIR, Muneer, Asif, HAZIR, BERK   +4 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A systematic review of clinical guidelines on the management of acute, community-acquired CNS infections

BMC Medicine, 2019
Background The epidemiology of CNS infections in Europe is dynamic, requiring that clinicians have access to up-to-date clinical management guidelines (CMGs) to aid identification of emerging infections and for improving quality and a degree of ...
Louise Sigfrid, Chelsea Perfect, Amanda Rojek, Kajsa-Stina Longuere, Sam Lipworth, Eli Harriss, James Lee, Alex Salam, Gail Carson, Herman Goossens, Peter Horby   +10 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source