Results 131 to 140 of about 52,487 (253)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Quality of Clinical Practice Guidelines for Diabetic Foot Management: A Systematic Review Using the AGREE II and AGREE-REX Instruments

open access: yesDiabetes, Metabolic Syndrome and Obesity
Yu Song,1,* Zhong-Fei Cui,2,* Zhi-Qiang Wu,1 Xiao-Bo Liu,1 Wu-Quan Li,3 Cai Zhu,1 Ting Que,1 Shan-Shan Zhao,4 Xiao-Ling Wang,1 Guo-Xun Yang,1 Wen-Jun Liu3 1Department of Burns, Plastics and Wound Repair Surgery, The First Affiliated Hospital of Dali University, Dali University, Dali, Yunnan, 671000, People’s Republic of China ...
Yu Song   +10 more
openaire   +3 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

open access: yesFEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Evidence-Based Clinical Practice Guidelines for the Assessment and Management of Chronic Kidney Disease: A Systematic Review and Quality Assessment Using the AGREE II Instrument

open access: yesSaudi Journal of Kidney Diseases and Transplantation
Clinical practice guidelines (CPGs) based on evidence and expert opinions ensure that patients with chronic kidney disease (CKD) receive the most up to date care. We aimed to assess and evaluate the most recent and approved international CPGs and compare
Mohamed Ali Babiker Mohamed   +10 more
doaj   +1 more source

Using Appraisal of Guidelines for Research & Evaluation II (AGREE II) Tool to evaluate the sepsis resuscitation bundle practice guideline [PDF]

open access: yes, 2013
Session presented on: Tuesday, July 23, 2013: Purpose: Nurses should detail clinical significance of practice guidelines, identify research criteria considered for clinical guideline development, synthesize literature used for the practice guideline\u27s
Pinelle, Michelle A., Roney, Jamie K.
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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