Results 151 to 160 of about 7,942,911 (287)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

PAIR: Evaluating the Limits of Agreement Among Non-Retinal Specialist Using PathFinder Artificial Intelligence Tool for Retinal Disease Referrals: A Prospective Observational Study. [PDF]

Clin Ophthalmol
Fong KCS, Wong WJ, Samsudin A, Ganasan DK, Goh WN, Tai JY, Fong SN, Cheong CYJ, Rajamanickam G, Shunmugam M.   +9 more
europepmc   +1 more source

Activity and learning agreement pilots : programme theory evaluation : working paper 4 : learning agreement provision [PDF]

, 2009
Johnson, Claire, Munro, Miranda, Page, Rosie   +2 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Precision diagnosis and therapy for pediatric central nervous system tumors: consensus from the Brazilian Society of Pediatric Oncology (SOBOPE). [PDF]

Lancet Reg Health Am
Farias de Alvarenga KA, Oliveira de Araújo J, Rezende da Silveira M, Silva NS, Coelho MR, Pimentel JA, Pereira Dos Reis A, Cappellano AM, Mançano BM, D'Almeida Costa F, Martins FD, Bellas GO, Teixeira GR, Gomy I, Gregianin LJ, Okamoto OK, Campregher PV, Camargo R, Ferman SE, Valera ET, Brazilian Committee of Precision Medicine in Pediatric Oncology (BC-PMPO) — the Brazilian Society of Pediatric Oncology (SOBOPE).   +20 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Repeatability, reproducibility, and agreement regarding measurement of choroidal vascularity index between OCT and OCT angiography. [PDF]

Int J Ophthalmol
Zhong MH, Zhang JL, Yu KX, Fan SQ, Li X, Chen H, Bao JH, Huang YY.   +7 more
europepmc   +1 more source

UNH and Lecturers Reach Labor Agreement [PDF]

, 2015
Corvey, Candace
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Comparison of CD34+ cell enumeration between flow cytometric analysis and ADAMII-CD34 image-based fluorescence cell counter. [PDF]

PLoS One
Thedsawad A, Boonmoh S, Taka O, Owattanapanich W.   +3 more
europepmc   +1 more source