Results 41 to 50 of about 8,332,394 (265)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Composition and Functional Specialists of the Gut Microbiota of Frogs Reflect Habitat Differences and Agricultural Activity

Frontiers in Microbiology, 2018
The physiological impact of agricultural pollution, habitat disturbance, and food source variability on amphibian remains poorly understood. By comparing the composition and predicted functions of gut microbiota of two frog species from forest and ...
Bing-Hong Huang, Chun-Wen Chang, Chun-Wen Chang, Chih-Wei Huang, Jian Gao, Jian Gao, Pei-Chun Liao   +6 more
doaj   +1 more source

A comparative study using response surface methodology and artificial neural network towards optimized production of melanin by Aureobasidium pullulans AKW

Scientific Reports, 2023
The effect of three independent variables (i.e., tyrosine, sucrose, and incubation time) on melanin production by Aureobasidium pullulans AKW was unraveled by two distinctive approaches: response surface methodology (i.e.
WesamEldin I. A. Saber, Abeer A. Ghoniem, Fatimah O. Al-Otibi, Mohammed S. El-Hersh, Noha M. Eldadamony, Farid Menaa, Khaled M. Elattar   +6 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Structural changes in land use of agricultural holdings in hilly rural areas

Acta Geographica Slovenica, 2015
This paper analyses structural changes in agricultural holdings in the Škofja Loka region focusing on land use in the years 2000 and 2010. The analysis is conducted for the Škofja Loka region by socio-economic types of agricultural holdings, and by ...
Kristina Knific, Štefan Bojnec
doaj   +1 more source

The concept of agricultural land as the subject of agricultural tax

Prawo Budżetowe Państwa i Samorządu, 2020
This article concerns the analysis of the scope of the agricultural tax in question. The research which has been carried out has led to the conclusion that the narrow methodology of determining basis for the assessment of agricultural classification as ...
Wojciech Gonet
doaj   +1 more source

Prediction of species composition ratios in pooled specimens of the Anopheles Hyrcanus group using quantitative sequencing

Malaria Journal, 2021
Background Plasmodium vivax is transmitted by members of the Anopheles Hyrcanus Group that includes six species in the Republic of Korea: Anopheles sinensis sensu stricto (s.s.), Anopheles pullus, Anopheles kleini, Anopheles belenrae, Anopheles lesteri ...
Do Eun Lee, Heung-Chul Kim, Sung-Tae Chong, Terry A. Klein, Ju Hyeon Kim, Si Hyeock Lee   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

INNOVATIVE ACTIVITIES OF AGRICULTURE IN UZBEKISTAN

World Science, 2019
This article reflects the issues of sustainable development of the agricultural sector of Uzbekistan, the innovative activity of the sector, as well as issues of effective management.
null Rustamova Dilsahon Djuraevna, null Makhmudov Odil Xalmirzaevich, null Yuldashev Akmaljon Mexmonovich   +2 more
openaire   +2 more sources

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source