This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang +11 more
wiley +1 more source
Editorial: Microbial solutions for restoring depleted soils. [PDF]
Mehnaz S, Shahid I, Walia A, Mumtaz MZ.
europepmc +1 more source
A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance
Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng +12 more
wiley +1 more source
Corigendum to "Integrative genomic analysis and gene expression patterns reveal a cardio-neuroendocrine signaling network for heat adaptation in geographically diverse chickens" [Poultry Science, Volume 105, Issue 6, June 2026, 106744]. [PDF]
Nawaz AH +12 more
europepmc +1 more source
Agricultural growth, poverty, and nutrition in Tanzania: [PDF]
Rapid economic growth has failed to significantly improve poverty and nutrition outcomes in Tanzania. This raises concerns over a decoupling of growth, poverty, and nutrition.
Thurlow, James, Pauw, Karl
core
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong +14 more
wiley +1 more source
Editorial: Non-chemical strategies for managing plant diseases and abiotic stresses. [PDF]
Adkar-Purushothama CR +2 more
europepmc +1 more source
Herbicide Metabolic Resistance in Poaceae Plants via the GA‐GID1/DELLA‐DOF2‐P450s Module
Plant hormone signaling modulates herbicide resistance in Echinochloa crus‐galli. The GA–DELLA–DOF2 cascade directly activates P450 detoxification genes in two Poaceae species, uncovering a core mechanism of metabolic herbicide resistance. ABSTRACT Barnyard grass (Echinochloa crus‐galli) is one of the world's most important weeds, and the evolution of ...
Junzhi Wang +6 more
wiley +1 more source
Node Position Determines Sweetpotato (<i>Ipomoea batatas</i> [L.] Lam.) Cutting Performance: Toward a Targeted Inverted Planting Strategy. [PDF]
Morales A +11 more
europepmc +1 more source

