Results 141 to 150 of about 227,222 (228)

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

open access: yesAdvanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng   +16 more
wiley   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

open access: yesAdvanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang   +6 more
wiley   +1 more source

Development of low-prolamin rice germplasm via CRISPR/Cas9 editing to improve eating and cooking quality. [PDF]

open access: yesJ Integr Plant Biol
Chen Z   +16 more
europepmc   +1 more source

Bio‐Inspired Gradient Coatings Enhance the Leading Edge Erosion Resistance of Wind Blades

open access: yesAdvanced Science, EarlyView.
Rain‐induced erosion of the wind turbine blade leading edge poses a critical challenge to maintenance and operation. Here, we propose a bio‐inspired approach for erosion protection utilising a platelet‐reinforced polyurethane coating with a graded through‐thickness architecture.
Natalia Sofia Guevara‐Sotelo   +2 more
wiley   +1 more source

Generation and Characterization of Novel Low-Amylose Rice Germplasm via Prime Editing of the <i>Wx</i> Promoter. [PDF]

open access: yesInt J Mol Sci
Liu J   +16 more
europepmc   +1 more source

TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice

open access: yesAdvanced Science, EarlyView.
This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo   +22 more
wiley   +1 more source

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

open access: yesAdvanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song   +9 more
wiley   +1 more source

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