Results 231 to 240 of about 870,323 (307)

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

open access: yesAdvanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma   +17 more
wiley   +1 more source

A Photothermal‐Responsive PRP‐Loaded Hydrogel Engineered With Composite Nanobottle for Controllable Delivery of Growth Factors and Multifunctional Therapy of Diabetic Wounds

open access: yesAdvanced Science, EarlyView.
A photothermal‐responsive engineered platelet‐rich plasma hydrogel (CNB‐ePRP) incorporated with thrombin‐functionalized composite nanobottle was developed, which enables in situ PRP activation, on‐demand growth factor release, multifunctionality, and personalized antimicrobial loading for treatment of diabetic wounds. The CNB‐ePRP hydrogel demonstrated
Wen‐Qiang Qu   +8 more
wiley   +1 more source

The Enhanced Whey Protein Oral Bioavailability and Muscle Anabolism Ability by a Simple and Effective Piperine‐Whey Protein Synergistic Codelivery System

open access: yesAdvanced Science, EarlyView.
WP(Pip) is a mixture of whey protein and piperine‐loaded nanoemulsion stabilized by WP through microfluidic homogenization. Acting as a “smart key,” piperine opens epithelial tight junctions to enhance absorption of whey protein and, thereby increasing circulating amino acid availability, synergistically up‐regulates the mTOR signaling pathway in ...
Qing Yue   +10 more
wiley   +1 more source

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu   +8 more
wiley   +1 more source

Time-Efficient and Informatic-Skill-Light Gap-Filling for Telomere-to-Telomere Genome Assembly. [PDF]

open access: yesAdv Sci (Weinh)
Xu D   +8 more
europepmc   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

open access: yesAdvanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li   +25 more
wiley   +1 more source

Actinomycetoma Due to Nocardia brasiliensis: Recognition in Primary Care. [PDF]

open access: yesCureus
Martínez-Ortega JI   +2 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy