Results 161 to 170 of about 124,978 (241)

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

open access: yesAdvanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu   +5 more
wiley   +1 more source

Electrical‐Stimulation Hydrogel Electronic Skin for Sustainable Hybrid Biomechanical–Electromagnetic Energy Harvesting and Accelerating Wound Healing

open access: yesAdvanced Science, EarlyView.
A hybrid biomechanical–electromagnetic energy‐harvesting e‐skin is developed using a gelatin‐based outer matrix with a zwitterionic conductive inner layer. The e‐skin autonomously generates stable electrical stimulation from daily body motion and ambient electronics, enabling significantly enhanced wound healing bothin vitro and in vivo.
Syun‐Hong Chou   +12 more
wiley   +1 more source

Closed‐Loop Radiative Cooling Mulch Upcycled From Agricultural Residues for Efficient Soil Heat–Water Stress Mitigation

open access: yesAdvanced Science, EarlyView.
Conventional passive radiative cooling films rely on costly feedstocks and energy‐intensive fabrication, with poor end‐of‐life compatibility in agriculture. To address this challenge, a sustainable radiative cooling mulch (SRCM) is developed from waste maize leaves via spontaneous hydrogen‐bond self‐assembly.
Hao Li   +13 more
wiley   +1 more source

Discriminator‐Guided Inverse Folding for Multi‐Property Protein Design

open access: yesAdvanced Science, EarlyView.
Discriminator‐Guided Inverse Folding (DGIF) integrates multiple property predictors trained from single‐property datasets to guide protein sequence generation from a backbone structure. DGIF enables simultaneous improvement of thermostability and solubility without requiring multi‐property annotated datasets and generates designs that move toward the ...
Yuchuan Zheng   +7 more
wiley   +1 more source

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