Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic
To enable incorporation of l‐2‐aminodecanoic acid into polymyxin by fermentation, a single Trp‐to‐Ala substitution is rationally introduced into the adenylation‐domain residue of its nonribosomal peptide synthetase (NRPS) and efficiently switches substrate selectivity. The engineered strain produces biologically active Ada‐polymyxin, demonstrating that
Maximilian Müll +7 more
wiley +2 more sources
Hydrochemical Characteristics and Evolution of Shallow Groundwater from the Piedmont Recharge Zone to the Coastal Plain Discharge Zone in Tangshan, North China Plain. [PDF]
Zhong X, Wang H, Li M, Qu Z, Hu S.
europepmc +1 more source
Highlights of agricultural research, Vol. 32, no. 3, Fall 1985
Bibliography of agriculture, 0006-1530. Chemical abstracts, 0009-2258. Cover title. Also available on microfilm from: Spaulding: Graphic Microfilm Division under title: State agricultural ...
Alabama Agricultural Experiment Station
core
Improving access to new technologies: An experiment with Kenyan input sellers
Abstract Agrodealers play a critical role in rural economies, selling essential inputs for agricultural production, stocking new products, and providing farmers with technical advice. However, uncertainty can discourage them from stocking newer, less familiar products, limiting the availability of innovative technologies and leading to market failures ...
Sarah W. Kariuki +6 more
wiley +1 more source
Carbon balance zoning and carbon budget drivers for governance in the Chengdu Chongqing urban agglomeration. [PDF]
Yu T +6 more
europepmc +1 more source
Highlights of agricultural research, Vol. 37, no. 4, Winter 1990
Bibliography of agriculture, 0006-1530. Chemical abstracts, 0009-2258. Cover title. Also available on microfilm from: Spaulding: Graphic Microfilm Division under title: State agricultural ...
Alabama Agricultural Experiment Station
core
Abstract Preserving ecosystem services, along with economic and environmental benefits, will require future landscape policies to identify and incorporate relevant landscape features. In this paper, we investigate the causal effect of agricultural landscape simplification on drought‐related grassland damages.
Marco Ferro +5 more
wiley +1 more source
Spatiotemporal patterns and optimization of dominant and recessive morphology of cultivated land use in the Ili River Valley. [PDF]
Zhou C, Fu L, Xiang H.
europepmc +1 more source
Highlights of agricultural research, Vol. 39, no. 1, Spring 1992
Bibliography of agriculture, 0006-1530. Chemical abstracts, 0009-2258. Cover title. Also available on microfilm from: Spaulding: Graphic Microfilm Division under title: State agricultural ...
Alabama Agricultural Experiment Station
core
Abstract This article examines the psychological effects of migration detention in the European Union's Closed Controlled Access Center (CCAC) on Samos through an ecological lens. It explores a double normalization of suffering: the brutalization of necropolitical migration governance and the simultaneous understanding of resulting distress as an ...
Julia Manek
wiley +1 more source

