Results 21 to 30 of about 4,706,773 (336)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Permanent Agriculture: Precursor to Organic Farming [PDF]
, 2006 The concept of Permanent Agriculture predates Organic Agriculture by thirty years. Following a clash with the USDA over the theory of soil fertility, American soil scientist Franklin King wrote "Farmers of Forty Centuries or Permanent Agriculture in ...
Paull, John
core
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Rethinking Oregon Agriculture [PDF]
, 2017 Darla (Goodnoe) Baggenstos ’90 is no stranger to farming. She grew up raising cattle, pigs and chickens in Tigard. After graduating from Linfield, she married Jim Baggenstos, a third-generation farmer at Baggenstos Farm just down the road from her family’
Feuerstein, Christian
core +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Changing Agriculture in a Changing Climate [PDF]
, 2012 Changes in weather patterns are going to affect agriculture with impacts differing according to region. The developing countries can reckon with the first effects. The authors look at the role that organic agriculture can play in adaptation.
Gattinger, Andreas +2 more
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Vision applications in agriculture [PDF]
, 2007 From early beginnings in work on the visual guidance of tractors, the National Centre for Engineering in Agriculture has built up a portfolio of projects in which machine vision plays a prominent part.
Billingsley, John
core +2 more sources
Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1
FEBS Letters, EarlyView.Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji +5 more
wiley +1 more source
Creating a Northern Agriculture. II. Historical Perspectives in Alaskan Agriculture [PDF]
, 1975 Much can be learned about the present status of agriculture in Alaska from a review of the long and varied history of Alaskan agriculture. At some times, concerted public efforts have been directed to its development; at others, agriculture has ...
Burton, Wayne E.
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Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source