Results 31 to 40 of about 64,959,702 (312)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

STANDARD CHARACTERIZATION OF RED ONION LANDRACES ‘DE BUZĂU’ AND ‘DE TURDA’ [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2017
To maintain food security, the conservation and sustainable use of all plant genetic resources for food and agriculture (PGRFA) is essential under the International Treaty on Plant Genetic Resources for Food and Agriculture (Plant Treaty) adopted in ...
Maria Mihaela ANTOFIE, Camelia SAVA SAND
doaj  

The conundrum of conservation agriculture and livelihoods in Southern Africa [PDF]

, 2011
Low crop productivity, food insecurity, hunger and malnutrition; inadequate farming knowledge and skills, implements and inputs are characteristic of smallholder agriculture in Southern Africa.
Nkala, P., Corbeels, M., Veldwisch, G.J.A., Corbeels, Marc, Huising, Jeoroen, Huising, J., Mango, N., Mango, Nelson, Jan Veldwisch, Gert, Nkala, Peter   +9 more
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Doubled-Up Legume Systems Under Conservation Agriculture and Conventional Agriculture in Sinda, Chipata, and Lundazi, Zambia

, 2018
This study contains data originated from on-farm trials that were conducted to test and demonstrate the crop yield and economic benefits derived from conservation agriculture (CA) systems on smallholder farms where the ridge and furrow tillage system is ...
Zambian Agriculture Research Institute (ZARI), International Maize and Wheat Improvement Center (CIMMYT), Total LandCare (TLC)   +2 more
core   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

Le loup en tribunes : analyse comparée de deux discours argumentatifs sur une espèce controversée [PDF]

Natures Sciences Sociétés, 2016
Cet article propose une approche discursive de la controverse liée à la présence du loup en France. L’analyse comparée de deux plaidoyers, l’un défavorable, l’autre favorable au retour de l’espèce, parus respectivement dans Libération
Chandelier Marie, Mathevet Raphaël, Steuckardt Agnès, Sarale Jean-Marc   +3 more
doaj   +1 more source