Results 291 to 300 of about 316,204 (367)

Leveraging Synteny to Generate Reference Genomes for Conservation: Assembling the Genomes of Hector's and Māui Dolphins

Molecular Ecology Resources, EarlyView.
ABSTRACT Escalating concern regarding the impacts of reduced genetic diversity on the conservation of endangered species has spurred efforts to obtain chromosome‐level genomes through consortia such as the Vertebrate Genomes Project. However, assembling reference genomes for many threatened species remains challenging due to difficulties obtaining ...
S. Alvarez‐Costes, C. S. Baker, R. Constantine, E. L. Carroll, J. Guhlin, L. Dutoit, S. Ferreira, D. Heimeier, N. J. Gemmell, J. Gillum, R. M. Hamner, W. Rayment, W. Roe, B. Te Aikā, L. Urban, A. Alexander   +15 more
wiley   +1 more source

Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice

Aging Cell, EarlyView.
Senolytic therapy restores neurovascular function, blood–brain barrier integrity, and cognitive performance in aged mice by targeting endothelial senescence. Findings highlight that brain microvascular endothelial cells are highly vulnerable to aging‐induced senescence, and early intervention in middle age may be the most effective strategy to prevent ...
Boglarka Csik, Ádám Nyúl‐Tóth, Rafal Gulej, Roland Patai, Tamas Kiss, Jordan Delfavero, Raghavendra Y. Nagaraja, Priya Balasubramanian, Santny Shanmugarama, Anna Ungvari, Siva Sai Chandragiri, Kiana Vali Kordestan, Mark Nagykaldi, Peter Mukli, Andriy Yabluchanskiy, Sharon Negri, Stefano Tarantini, Shannon Conley, Tae Gyu Oh, Zoltan Ungvari, Anna Csiszar   +20 more
wiley   +1 more source

Burden and Predictors of Statin Use for Primary and Secondary Prevention of Cardiovascular Disease in Bangladesh: Evidence from a Nationally Representative Survey. [PDF]

Glob Heart
Al Abid SU, Monower MM, Abrar AK, Riva JA, Bhuiyan MR, Al-Mamun MA, Choudhury SR.   +6 more
europepmc   +1 more source

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN‐2‐Mediated Changes

Aging Cell, EarlyView.
Changes in mitochondrial structure and dynamics during aging provide a mechanism for the development of age‐related sarcopenia, a condition characterized by muscle mass loss. Through the creation of three‐dimensional models of mitochondria from quadriceps muscle tissue taken from old and young humans, a loss in mitochondrial complexity was observed to ...
Estevão Scudese, Andrea G. Marshall, Zer Vue, Vernat Exil, Benjamin I. Rodriguez, Mert Demirci, Larry Vang, Edgar Garza López, Kit Neikirk, Bryanna Shao, Han Le, Dominique Stephens, Duane D. Hall, Rahmati Rostami, Taylor Rodman, Kinuthia Kabugi, Jian‐qiang Shao, Margaret Mungai, Salma T. AshShareef, Innes Hicsasmaz, Sasha Manus, Celestine N. Wanjalla, Aaron Whiteside, Revathi Dasari, Clintoria R. Williams, Steven M. Damo, Jennifer A. Gaddy, Brian Glancy, Estélio Henrique Martin Dantas, André Kinder, Ashlesha Kadam, Dhanendra Tomar, Fabiana Scartoni, Matheus Baffi, Melanie R. McReynolds, Mark A. Phillips, Anthonya Cooper, Sandra A. Murray, Anita M. Quintana, Nelson Wandira, Okwute M. Ochayi, Magdalene Ameka, Annet Kirabo, Sepiso K. Masenga, Chanel Harris, Ashton Oliver, Pamela Martin, Amadou Gaye, Olga Korolkova, Vineeta Sharma, Bret C. Mobley, Prasanna Katti, Antentor Hinton   +52 more
wiley   +1 more source

Metal-Induced Amide Deprotonation and Binding Typical for Cu(II), Not Possible for Zn(II) and Fe(II). [PDF]

Inorg Chem
Leveraro S, Dzyhovskyi V, Garstka K, Szebesczyk A, Zobi F, Bellotti D, Stokowa-Sołtys K, Remelli M, Rowińska-Żyrek M.   +8 more
europepmc   +1 more source

ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction).

, 2004
Elliott M. Antman, Daniel T. Anbe, Paul W. Armstrong, Eric Bates, Lee A. Green, Mary M. Hand, Judith S. Hochman, Harlan M. Krumholz, Frederick G. Kushner, Gervasio A. Lamas, Charles J. Mullany, Joseph P. Ornato, David L. Pearle, Michael A. Sloan, Sidney C. Smith, Joseph S. Alpert, Jeffrey L. Anderson, David P. Faxon, Valentı́n Fuster, Raymond J. Gibbons, Gabriel Gregoratos, Jonathan L. Halperin, Loren F. Hiratzka, Sharon A. Hunt, Alice K. Jacobs   +24 more
openalex   +2 more sources

Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches

Aging Cell, EarlyView.
Supplementation with the natural senolytic agent fisetin attenuated age‐related declines in physical function in mice. Better physical function with fisetin was accompanied by lower expression of cell senescence‐related genes. Fisetin treatment had comparable effects on physical function as genetic clearance of senescent cells and synthetic senolytic ...
Kevin O. Murray, Sophia A. Mahoney, Katelyn R. Ludwig, Jill H. Miyamoto‐Ditmon, Nicholas S. VanDongen, Nirad Banskota, Allison B. Herman, Douglas R. Seals, Robert T. Mankowski, Matthew J. Rossman, Zachary S. Clayton   +10 more
wiley   +1 more source

Pre-test probability estimation of coronary artery disease can be improved by adding an acoustic-based risk score. [PDF]

Int J Cardiol Heart Vasc
Bjerking LH, Schmidt SE, Skak-Hansen KW, Winther S, Böttcher M, Galatius S, Prescott E.   +6 more
europepmc   +1 more source

Late Life Supplementation of 25‐Hydroxycholesterol Reduces Aortic Stiffness and Cellular Senescence in Mice

Aging Cell, EarlyView.
25‐hydroxycholesterol (25HC) targets senescent cell anti‐apoptotic pathways (SCAPs) to reduce vascular cell senescence, favorably remodel aortic wall components, and reduce aortic stiffening with advancing age. ABSTRACT Stiffening of the aorta is a key antecedent to cardiovascular diseases (CVD) with aging.
Sophia A. Mahoney, Mary A. Darrah, Ravinandan Venkatasubramanian, Serban Ciotlos, Matthew J. Rossman, Judith Campisi, Douglas R. Seals, Simon Melov, Zachary S. Clayton   +8 more
wiley   +1 more source