Results 241 to 250 of about 207,625 (321)

Sevoflurane Inhibits Layer 5 Pyramidal Neurons via Kv1.2‐Dependent Modulation of Subthreshold Currents

open access: yesJournal of Neurochemistry, Volume 170, Issue 1, January 2026.
General anesthetics suppress cortical activity, but their cellular mechanisms remain unclear. We investigated how the volatile anesthetic sevoflurane affects layer 5 pyramidal neurons in the auditory cortex. Using patch‐clamp recordings and computational modeling, we found that low‐dose sevoflurane reduces neuronal firing through Kv1.2 channel ...
Aelton S. Araujo   +4 more
wiley   +1 more source

New cases of δ‐aminolevulinic acid dehydratase deficiency: Functional insights into gene variants using an innovative mouse liver model

open access: yesJournal of Internal Medicine, Volume 299, Issue 1, Page 126-142, January 2026.
Abstract Background Dysfunction of δ‐aminolevulinic acid dehydratase (ALAD), the second enzyme involved in heme biosynthesis, leads to two pathologies: genetic and acquired. The genetic form is an ultrarare, severe childhood‐onset disease inherited in an autosomal recessive manner, whereas the acquired form usually affects adults due to enzyme ...
Elena Di Pierro   +22 more
wiley   +1 more source

Feasibility and efficacy of mobile app implementation among patients with acute myocardial infarction enrolled in coordinated cardiac rehabilitation program. [PDF]

open access: yesFront Digit Health
Harpula J   +10 more
europepmc   +1 more source

PLETHORAs shape Arabidopsis phyllotaxis through modulation of patterning robustness and accelerated inflorescence development

open access: yesNew Phytologist, Volume 249, Issue 1, Page 495-511, January 2026.
Summary Phyllotaxis is the arrangement of lateral organs on a stem axis, which in Arabidopsis follows a spiral pattern. We previously described that loss of three PLETHORA (PLT) transcription factors shifts the phyllotactic spiral to novel metastable patterns, but the mechanism behind these shifts remained unclear.
Merijn Kerstens   +4 more
wiley   +1 more source

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