Results 21 to 30 of about 270,130 (220)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Human Mobility Datasets in the Complex Metro System of Shanghai

Scientific Data
The growing role of metro systems in urban mobility calls for high-quality metro transit datasets. Derived from over 700 million smart card records, an open-sourced, city-scale metro flow dataset was constructed, covering the period of May-August 2017 ...
Peiyan Sun, Jinming Yang, Zongyuan Huang, Shaoyu Huang, Shengyuan Xu, Weipeng Wang, Wenxuan Guo, Yuting Feng, Xi Zhai, Tao Yang, Xiaokang Yang, Yaohui Jin, Yanyan Xu   +12 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

DialogueNeRF: towards realistic avatar face-to-face conversation video generation

Visual Intelligence
Conversation is an essential component of virtual avatar activities in the metaverse. With the development of natural language processing, significant breakthroughs have been made in text and voice conversation generation.
Yichao Yan, Zanwei Zhou, Zi Wang, Jingnan Gao, Xiaokang Yang   +4 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

LITP-GAN: Leaf image translation pipeline using DETR and GLA-Net considering the lesion area of plant disease

Journal of King Saud University: Computer and Information Sciences
Quick disease diagnosis is crucial in agriculture to reduce crop yield losses. Deep learning techniques have already been successfully applied to several tasks in agriculture, but it requires sufficient datasets. Obtaining sufficient plant disease images
Ri Zheng, Jimin Lee, Helin Yin, Dong Jin, Yeong Hyeon Gu   +4 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Human mobility prediction with causal and spatial-constrained multi-task network

EPJ Data Science
Modeling human mobility helps to understand how people are accessing resources and physically contacting with each other in cities, and thus contributes to various applications such as urban planning, epidemic control, and location-based advertisement ...
Zongyuan Huang, Shengyuan Xu, Menghan Wang, Hansi Wu, Yanyan Xu, Yaohui Jin   +5 more
doaj   +1 more source