Results 21 to 30 of about 83,762 (267)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

AI-Driven Learning: Mediating and Moderating Dynamics in Self-Regulated Learning.

Journal of EST (Educational Science And Technology)
The rapid integration of artificial intelligence (AI) in education has transformed how students learn, particularly in fostering self-regulated learning (SRL).
Melda Mahniza, Resti Elma Sari, Puji Hujria Suci, Indra Saputra, Elviza Yeni Putri   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Who Wants to Try AI? Profiling AI Adopters and AI‐Trusting Publics in South Korea

Media and Communication
The study introduces new approaches that integrate public relations concepts to identify adopters of AI technologies. It seeks to discover novel methods for identifying target groups likely to adopt AI technologies, even in contexts where these ...
Hyelim Lee, Changyoung Jung, Nayoung Koo, Seongbeom Seo, Sangbong Yoo, Hyein Hong, Yun Jang   +6 more
doaj   +1 more source

Responsible AI Adoption in the Public Sector: A Data-Centric Taxonomy of AI Adoption Challenges

Proceedings of the Annual Hawaii International Conference on System Sciences
Despite Artificial Intelligence (AI) transformative potential for public sector services, decision-making, and administrative efficiency, adoption remains uneven due to complex technical, organizational, and institutional challenges. Responsible AI frameworks emphasize fairness, accountability, and transparency, aligning with principles of trustworthy ...
Nikiforova, Anastasija, Lněnička, Martin, Melin, Ulf, Valle-Cruz, David, Gill, Asif, Cesar, Casiano-Flores, Sirait, Emyana, Luterek, Mariusz, Dreiling, Richard Michael, Tesarova, Barbora   +9 more
openaire   +4 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Dual Impact of AI Adoption on College Students’ Academic Performance in Music Education: Evidence from China

SAGE Open
Artificial Intelligence (AI) has fundamentally transformed knowledge production and dissemination. It has revolutionized educational paradigms, especially in music education.
Linlin Wei, Lu Qiu, Shuyu Man
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source