Results 61 to 70 of about 403,861 (273)

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li   +15 more
wiley   +1 more source

EFEKTIVITAS REGRESI KUANTIL DALAM MENGATASI PONTENSIAL PENCILAN

open access: yesBarekeng, 2020
Quantile regression as a robust regression method can be used to overcome the impact of unusual cases on regression estimates such as the presence of potential outliers in the data.
Netti Herawati
doaj   +1 more source

Two Dimensional Clustering of Gamma-Ray Bursts using durations and hardness

open access: yes, 2017
Gamma-Ray Bursts (GRBs) have been conventionally bifurcated into two distinct categories: ``short'' and ``long'' with durations less than and greater than two seconds respectively. However, there is a lot of literature (although with conflicting results)
Bhave, Aishwarya   +3 more
core   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

open access: yesAdvanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu   +7 more
wiley   +1 more source

Neurofibromatosis type 1: Surgical Perspectives

open access: yesThe Annals of African Surgery, 2011
Introduction: Neurofibromatosis type 1 (NF1) affects about 1 in 3000 people. The indications for surgical intervention in patients with NF1 are not always clear-cut.
Nthumba PM, MMed(Surg),FCS(ECSA), Plastic Surgery Fellowship   +1 more
doaj  

HIV viral load suppression and associated factors among PLHIV with non-communicable diseases in Uganda’s Teso Region: a cross-sectional retrospective study

open access: yesAIDS Research and Therapy
Background As Uganda scales up integrated chronic care, understanding viral load suppression (VLS) among people living with HIV (PLHIV) with non-communicable diseases (NCDs) is critical for optimizing service delivery.
Bonniface Oryokot   +8 more
doaj   +1 more source

Long‐Tea‐CLIP: An Expert‐Level Multimodal AI Framework for Fine‐Grained Green Tea Grading Across Five Sensory Dimensions

open access: yesAdvanced Science, EarlyView.
Long‐Tea‐CLIP (Contrastive Language‐Image Pre‐training) presents a multimodal AI framework that integrates visual, metabolomic, and sensory knowledge to grade green tea across appearance, soup color, aroma, taste, and infused leaf. By combining expert‐guided modeling with CLIP‐supervised learning, the system delivers fine‐grained quality evaluation and
Yanqun Xu   +9 more
wiley   +1 more source

Combining predictions from linear models when training and test inputs differ [PDF]

open access: yes, 2014
Methods for combining predictions from different models in a supervised learning setting must somehow estimate/predict the quality of a model's predictions at unknown future inputs.
van Ommen, Thijs
core   +2 more sources

Engineering New‐to‐Nature Biological Pathways for β,γ‐Alkanediol Synthesis

open access: yesAdvanced Science, EarlyView.
β,γ‐Alkanediols are value‐added chemicals to be used as functional solvents, biofuels, and cosmetic components. This work demonstrates a carboligation‐mediated approach for synthesis of linear chain β,γ‐alkanediols in Escherichia coli, namely, hexane‐2,3‐diol (2,3‐HDO) and pentane‐2,3‐diol (2,3‐PDO). The engineered E. coli cells produce 152.2 mm (17.98
Haofeng Chen   +6 more
wiley   +1 more source

Model Selection Criteria for the Leads-and-Lags Cointegrating Regression [PDF]

open access: yes
In this paper, Mallows'(1973) Cp criterion, Akaike's (1973) AIC, Hurvich and Tsai's (1989) corrected AIC and the BIC of Akaike (1978) and Schwarz (1978) are derived for the leads-and-lags cointegrating regression.
Eiji Kurozumi, In Choi
core   +3 more sources

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