Results 31 to 40 of about 93,993 (298)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Does aid for trade promote green product exports in recipient countries?

Development Studies Research
This study examines the impact of Aid for Trade (AfT) on green product exports across 126 recipient countries over the period 2002–2021. The empirical analysis employs fixed-effects estimations as the baseline approach and system GMM estimations for ...
Nguyen Thi Thu Huong, Bui Thi Thanh Nga
doaj   +1 more source

CUSTOMS EXEMPTIONS AS A FORM OF PUBLIC AID FOR ENTREPRENEURS [PDF]

Zeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-Białej, 2015
One form of public aid provided for entrepreneurs involved in international trade turnover consists in exempting from customs duty by a customs administration body from the obligation to pay import or export customs receivables.
Adam Drozdek
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

How to Use an Optimization-Based Method Capable of Balancing Safety, Reliability, and Weight in an Aircraft Design Process

Nuclear Engineering and Technology, 2017
In order to help decision-makers in the early design phase to improve and make more cost-efficient system safety and reliability baselines of aircraft design concepts, a method (Multi-objective Optimization for Safety and Reliability Trade-off) that is ...
Cristina Johansson, Micael Derelöv, Johan Ölvander   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Agricultural development in the presence of foreign divestment: Policy options

Journal of Agriculture and Food Research, 2022
Following the implications of the loss of employment, revenue, foreign exchange, and the negative impact on overall agricultural development resulting from foreign divestment, estimates of the extent of foreign divestment on agricultural development and ...
Justice G. Djokoto, Ferguson Korbla Gidiglo, Francis Yao Srofenyoh, Kofi Aaron A-O Agyei-Henaku, Charlotte Badu Prah, Akua Agyeiwaa Afrane Arthur   +5 more
doaj   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Agricultural trade and IMF tariff conditionality in Sub-Saharan Africa

Scientific African
International trade is vital for inclusive growth and poverty reduction. Despite tariff reductions in Sub-Saharan Africa (SSA), the effectiveness of Aid for Trade (AfT) and International Monetary Fund (IMF) Structural Adjustment Programs (SAPs) in ...
Seboka Alemu, Balázs Kotosz
doaj   +1 more source