Results 41 to 50 of about 236,306 (240)

Multisystem cytomegalovirus end-organ disease in a patient with advanced HIV

Southern African Journal of Infectious Diseases, 2022
Cytomegalovirus (CMV) infection is common in people living with HIV, but multisystem CMV end-organ disease (EOD) is rare following the introduction of effective antiretroviral therapy.
Ruan Spies, Pierre Joubert, Dharshnee Chetty, Sipho Dlamini, Muhammed S. Moosa   +4 more
doaj   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Living with HIV: a qualitative research

Payesh, 2013
Objective (s): To investigate on consequences of living with HIV/AIDS. Methods: This was a qualitative study. Initially we selected a convenience sample and then narrowed-down the sample by maximum diversity in terms of age and education.
Homeira Fallahi, Sedigheh Sadat Tavafian, Farideh Yaghmaie, Ebrahim Hajizadeh   +3 more
doaj  

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

The magnitude of opportunistic infections and associated factors in HIV-infected adults on antiretroviral therapy in southern zone Tigray, Ethiopia: a cross-sectional study

The Pan African Medical Journal, 2020
INTRODUCTION: Greater than twenty known opportunistic infections have been associated with HIV infection and usually patients experience co-infections during the stage of illness, HIV-related opportunistic infections are associated with significant ...
Teklay Zeru Weldearegawi, Hadgu Gerensea, Hagos Berihu, Gebreamlak Gidey, Mebrahtom Zeru Welearegay   +4 more
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Bacterial urinary tract infections and its relation with CD4+ T lymphocyte cell count among people living with HIV in Ajmer City, Center of Rajasthan

Journal of Family Medicine and Primary Care, 2022
Introduction: Acquired immunodeficiency syndrome (AIDS) is a global health problem which weakens the immune system and makes it vulnerable to secondary opportunistic infections such as urinary tract infections (UTIs).
Jyotsna Chandwani, Preeti Meena, Surbhi Mathur, Geeta Parihar   +3 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Vulnerabilidade de adolescentes afrodescencentes e brancos em relação ao HIV/Aids

Estudos de Psicologia (Campinas)
Trata-se de um estudo quantitativo e comparativo entre adolescentes brancos e afrodescendentes sobre vulnerabilidade ao HIV/Aids. A amostra não é randômica e foi formada por 715 estudantes do ensino público noturno de escola de periferia de Santa ...
Brigido Vizeu Camargo, Andréia Isabel Giacomozzi, João Fernando Rech Wachelke, Adriana de Aguiar   +3 more
doaj   +1 more source