Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Report from the Commission to the Council and the European Parliament concerning Advanced Informatics in Medicine (AIM). Final report on performance and results. SEC (91) 1420 final, 25 July 1991 [PDF]
, 1991 core
Social policy and income distribution: An empirical analysis for the Netherlands
In most OECD-countries income inequality has increased during the last two decades. In this paper, we investigate to what extent changes in the overall distribution of incomes can be attributed to social policy measures.
Caminada, Koen, Goudswaard, Kees
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Integrating multi-omics analysis and machine learning to refine molecular subtypes and prognostic assessment of lower-grade glioma. [PDF]
Mol Ther OncolJiang Q +7 more
europepmc +1 more source
Communication from the Commission to the Council and the European Parliament concerning Advanced Informatics in Medicine (AIM): progress report '89 and mid-term review. SEC (89) 2048 final, 20 December 1989 [PDF]
, 1989 core
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
A Multicenter Retrospective Outcomes Analysis of Patients with Localized Synovial Sarcoma. [PDF]
Cancer Res CommunTesta S +14 more
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source