Results 41 to 50 of about 4,623,161 (291)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Air-Coupled Lamb Wave Testing of Buried Air-Voids in Foam-Filled Sandwich Panels

IEEE Open Journal of Ultrasonics, Ferroelectrics, and Frequency Control
Sandwich panels, composed of two steel faces and a rigid foam core, are an inexpensive and lightweight option for construction industry. However, voids can form in the foam core during the manufacturing process.
Christoph Haugwitz, Andre Reinartz, Jan-Helge Dorsam, Sonja Wismath, Gianni Allevato, Jan Hinrichs, Paulina Gorol, Annalena Kuhn, Thomas Hahn-Jose, Jorg Lange, Mario Kupnik   +10 more
doaj   +1 more source

High-frequency air-coupled transducers [PDF]

The Journal of the Acoustical Society of America, 1990
High-frequency air-coupled ultrasonic transducers are used in industrial applications for detecting or ranging with high resolution. The improvement of the coupling between PZT and air is of importance for the transducer performance. Unfortunately, it is difficult to find a material with proper acoustical impedance and small attenuation at high ...
Xiaoqi Bao, Vasundara V. Varadan, Vijay K. Varadan   +2 more
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Mass Transfer Study on Drying of Curdlan by Hot Air Coupled with Ultrasound and Infrared Irradiation and Quality Analysis

Shipin gongye ke-ji
Objective: Hot air coupled with ultrasound and infrared irradiation were used for the drying of curdlan. The drying mechanism and quality change of curdlan were explored under the multi-physical fields, so as to developing the green drying technology of ...
Hongqian WANG, Qinyu DAI, Rui ZHU, Chong ZHANG, Yongbin HAN, Dandan LI, Yang TAO   +6 more
doaj   +1 more source

Development of Fuel Debris Inspection Methods using Air-Coupled Ultrasound

E3S Web of Conferences, 2018
Japan has decided to start fuel debris removal on 2021. Therefore, before starting retrieval of the fuel debris, investigation of location, shape, and also properties of fuel debris have to be performed.
Hamdani Ari, Kikura Hiroshige, Kimura Shun, Tsukada Keisuke, Sasa Daisuku, Oomori Shuichi   +5 more
doaj   +1 more source