Results 41 to 50 of about 489,422 (286)
Influence of Arctic sea-ice variability on Pacific trade winds. [PDF]
, 2020 A conceptual model connecting seasonal loss of Arctic sea ice to midlatitude extreme weather events is applied to the 21st-century intensification of Central Pacific trade winds, emergence of Central Pacific El Nino events, and weakening of the North ...
Kennel, Charles F, Yulaeva, Elena
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
The Northwest Tropical Atlantic Station (NTAS) : NTAS-14 mooring turnaround cruise report [PDF]
, 2015 The Northwest Tropical Atlantic Station (NTAS) was established to address the need for accurate air-sea flux estimates and upper ocean measurements in a region with strong sea surface temperature anomalies and the likelihood of significant local air ...
Bigorre, Sebastien P. +4 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Influence of Wave State and Sea Spray on the Roughness Length: Feedback on Medicanes
Atmosphere, 2018 Occasionally, storms that share many features with tropical cyclones, including the presence of a quasi-circular “eye” a warm core and strong winds, are observed in the Mediterranean.
Umberto Rizza +9 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Scientific Reports, 2022 Some of the heaviest snowfalls in urban areas in the world occur in Japan, particularly in regions that face the Japan Sea. Many heavy snowfalls are produced by a Japan Sea polar air mass convergence zone (JPCZ), which is an atmospheric river-like cloud ...
Yoshihiro Tachibana +6 more
doaj +1 more source
Frontiers in Marine Science, 2021 The reliability of surface net heat flux data obtained from the latest satellite-based estimation [the third-generation Japanese Ocean Flux Data Sets with Use of Remote Sensing Observations (J-OFURO3, V1.1)] was investigated. Three metrics were utilized:
Hiroyuki Tomita +3 more
doaj +1 more source