Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Using eddy covariance to measure the dependence of air–sea CO2 exchange rate on friction velocity [PDF]
, 2017 Parameterisation of the air–sea gas transfer velocity of CO2 and other trace gases under open-ocean conditions has been a focus of air–sea interaction research and is required for accurately determining ocean carbon uptake. Ships are the most widely used
Bell, TG +5 more
core +9 more sources
Modern Statistical Methods in Oceanography: A Hierarchical Perspective
, 2013 Processes in ocean physics, air-sea interaction and ocean biogeochemistry span enormous ranges in spatial and temporal scales, that is, from molecular to planetary and from seconds to millennia.
Herbei, Radu +3 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Air‐sea interaction between tropical cyclone Nari and Kuroshio
Geophysical Research Letters, 2008 The air‐sea interaction between tropical cyclone Nari (Sep/6–16/2001) and Kuroshio is studied using satellite observations and an ocean model. Nari crossed the Kuroshio several times, which caused variations in typhoon intensity.
Chau‐Ron Wu +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Distinct influence of air–sea interactions mediated by mesoscale sea surface temperature and surface current in the Arabian Sea [PDF]
, 2004 Author Posting. © American Meteorological Society, 2017. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution.
Seo, Hyodae
core +3 more sources
The Northwest Tropical Atlantic Station (NTAS) : NTAS-17 mooring turnaround cruise report cruise on board FV Pisces May 30 – June 21, 2018 Mayport, FL, USA – Morehead City, NC, USA [PDF]
, 2018 The Northwest Tropical Atlantic Station (NTAS) was established to address the need for accurate air-sea flux estimates and upper ocean measurements in a region with strong sea surface temperature anomalies and the likelihood of significant local air ...
Bigorre, Sebastien P. +4 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Study on the air-sea interaction on the Baiu frontal zone using JCOPE2 and JCDAS [PDF]
, 2012 ACG36-08発表要旨 / 日本地球惑星科学連合2012年大会（2012年5月20日～5月25日, 幕張メッセ国際会議場 ...
MOTEKI, Kosaku, 茂木, 耕作
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