Results 221 to 230 of about 8,993,127 (335)

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

open access: yesAdvanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai   +7 more
wiley   +1 more source

A Preclinical Multifunctional Capsule Robot with Unified Diagnosis and Targeted Thermal Therapy for Gastrointestinal Diseases

open access: yesAdvanced Science, EarlyView.
A proof‐of‐concept multifunctional capsule robot integrates diagnostic imaging, magnetic navigation, wireless power transfer, and targeted thermotherapy for gastrointestinal applications. Magnetically guided positioning and stable wireless power enable localized thermal ablation, achieving controlled heating and high cell mortality in vitro.
Heng Zhang   +7 more
wiley   +1 more source

Force‐Electric Nanotentacles of Tantalum Implant Accelerate Cellular Energy Metabolism/Crosstalk for Immunomodulation‐Vascularized Bone Integration

open access: yesAdvanced Science, EarlyView.
A biomimetic force‐electric nanotentacle‐enabled tantalum (Ta) implant with surface‐nanostructured LiTaO3 (n‐LiTaO3) was first developed via laser nanofabrication combined with Li+‐induced in situ reaction, enabling the transduction of ultrasound into bioelectrical cues.
Taixing Zhang   +15 more
wiley   +1 more source

Achieving High‐Instantaneous Pulse Power in Contact‐Separation TENG via Series Capacitive Voltage Control Architecture

open access: yesAdvanced Science, EarlyView.
Conventional contact‐separation triboelectric nanogenerators generate high voltage but deliver limited power due to premature charge dissipation. Here, a capacitive charge reservoir architecture decouples charge accumulation from discharge triggering, enabling sequential voltage amplification via floating‐layer capacitive coupling.
Ajay Haridas CP   +3 more
wiley   +1 more source

Multifunctional Quantum Sensing Using Single Spins in a van der Waals Crystal

open access: yesAdvanced Science, EarlyView.
The work demonstrates a dual quantum sensing of temperature and magnetic field using spin‐complex quantum emitters in hexagonal boron nitride (hBN). Temperature sensing via zero‐phonon‐line shifts and magnetometry via optically detected magnetic resonances, enable simultaneous local thermometry and magnetic‐field measurements.
James Liddle‐Wesolowski   +7 more
wiley   +1 more source

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