Results 51 to 60 of about 8,047,439 (286)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Economic instruments for reduction of greenhouse gas emission in agriculture and forestry [PDF]
Ekonomika Poljoprivrede (1979), 2018 A significant reduction of greenhouse gas emissions in agriculture and forestry can be achieved with adequate economic instruments. There are also other measures on disposal, such as good agricultural practice and organic production that involve the use ...
Pešić Radmilo +2 more
doaj
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
An Integrated Analysis Approach to Unravel the Aspergillus Community in the Hospital Environment
Journal of FungiThe genus Aspergillus, widely distributed across natural and urban environments, may cause allergies and opportunistic infections such as chronic or invasive pulmonary aspergillosis.
Laura García-Gutiérrez +2 more
doaj +1 more source
Harmoni Lingkungan di Dunia Tarekat Qadiriyah wa Naqsabandiyah Desa Lalang Tanjung, Riau
Al-Tahrir, 2017 : The ecological crisis has caused destructions such as global warming, forest fires, droughts, floods, erosion, and pollution. It encourages people, including the tarekat followers, to make efforts to improve or harmonize ecology. This article describes
Masduki Masduki +2 more
doaj +1 more source
Compressible Air Entrapment in High-Speed Drop Impacts on Solid Surfaces
, 2012 Using high-speed photography coupled with optical interference, we experimentally study the air entrapment during a liquid drop impacting a solid substrate.
Liu, Yuan, Tan, Peng, Xu, Lei
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
About sorption-catalytic air cleaning in premises for people habitation in megapolises [PDF]
Инженерно-строительный журнал, 2011 The basic sources of pollution of the air environment in megapolises, and also of internal atmosphere of premises for people habitation, in respect of their possible clearing by sorption-catalytic methods are systematized.
A.V. Cрechevichkin +2 more
doaj
Радиационная гигиена, 2018 The article presents the results of alpha, gamma spectrometric analyzes of samples, dosimetry, radon monitoring of the estimated areas in the Istiklol city. It has been established that the specific activity of radionuclides for uranium and radium in the
Kh. M. Nazarov +4 more
doaj +1 more source