Results 41 to 50 of about 3,064,982 (300)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Automated ventilation control in mines. Challenges, state of the art, areas for improvement

Записки Горного института, 2020
The article is divided into three main parts. The first part provides an overview of the existing literature on theoretical methods for calculating the optimal air distribution in mines according to the criteria of energy efficiency and providing all ...
Mikhail A. Semin, Evgenii L. Grishin, Lev Yu. Levin, Artem V. Zaitsev   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The distributed air wing

, 2014
The development of advanced anti-access/area denial (A2AD) threats by potential adversaries presents a significant challenge to the United States Navy. The proliferation of these threats makes operating an aircraft carrier from contested waters a high-risk endeavor.
Naccarato, Vincent, Lee, Joong Yang, Wu, Meng Hsi, Ilan, Ittai Bar, Efird, James, Elzner, Benjamin, Morgan, Darrell, Tawoda, Kayla, Wolfe, Evan, Goh, Wei Jun, Loo, Sok Hiang, Ng, Kok Wah, Ong, Chee Siong, Tan, Choon Ming, Tan, Hock Woo, Tng, Chung Siong, Yang, Kangjie, SEA Cohort SEA-20B   +17 more
openaire   +2 more sources

Modeling of air flow in industrial rooms

Selected Scientific Papers: Journal of Civil Engineering, 2018
The article is devoted to the air distribution in a room by swirl and laying air jets. Dynamic parameters of air flow that is created due to swirl and laying air jets at their leakage in a room has been determined.
Yurkevych Yuriy, Sukholova Iryna, Kasynets Mariana   +2 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Emergent behavior of soil fungal dynamics:influence of soil architecture and water distribution [PDF]

, 2012
Macroscopic measurements and observations in two-dimensional soil-thin sections indicate that fungal hyphae invade preferentially the larger, air-filled pores in soils. This suggests that the architecture of soils and the microscale distribution of water
Baveye, Philippe C., Falconer, Ruth E., Houston, Alasdair N., Otten, Wilfred   +3 more
core   +3 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Gas turbine combustor insensitive to compressor outlet distortion [PDF]

, 1970
Short-length annular combustor for turbojet engines eliminates change of exit temperature profile. Individual scoops of full annular height control air distribution so that shifts in the radial velocity profile of air entering the combustor will not ...
Humenik, F., Norgren, C. T.
core   +1 more source